tert-butyl 4-(methylsulfonyl)-5-oxo-2-phenyl-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate

Base Information

Chemical Name:tert-butyl 4-(methylsulfonyl)-5-oxo-2-phenyl-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate
CAS No.:1345014-05-2
Molecular Formula:C₂₀H₂₂N₂O₅S
Molecular Weight:402.471
Hs Code.:

Synonyms:tert-butyl 4-(methylsulfonyl)-5-oxo-2-phenyl-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate

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Chemical Property of tert-butyl 4-(methylsulfonyl)-5-oxo-2-phenyl-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate

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Technology Process of tert-butyl 4-(methylsulfonyl)-5-oxo-2-phenyl-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate

There total 4 articles about tert-butyl 4-(methylsulfonyl)-5-oxo-2-phenyl-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1345013-95-7
tert-butyl 4-(methylthio)-5-oxo-2-phenyl-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate

: 1345014-05-2
tert-butyl 4-(methylsulfonyl)-5-oxo-2-phenyl-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 5 - 20 ℃; for 2.5h;

Reference yield:

: 1345013-92-4
tert-butyl 3-[bis(methylthio)methylene]-2,4-dioxopiperidine-1-carboxylate

: 1345014-05-2
tert-butyl 4-(methylsulfonyl)-5-oxo-2-phenyl-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium tert-butylate / dimethyl sulfoxide; tetrahydrofuran / 2.5 h

1.2: 2 h / 90 °C

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2.5 h / 5 - 20 °C

With potassium tert-butylate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;

Reference yield:

: C₂₀H₂₃NO₅S

: 1345014-05-2
tert-butyl 4-(methylsulfonyl)-5-oxo-2-phenyl-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium acetate; acetic acid / dimethyl sulfoxide; tetrahydrofuran / 2 h / 90 °C

2: 3-chloro-benzenecarboperoxoic acid / 2 h / 5 - 25 °C

With ammonium acetate; acetic acid; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dimethyl sulfoxide;
DOI:10.1016/j.tetlet.2013.06.016