tert-butyl 4-(methylthio)-5-oxo-2-phenyl-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate

Base Information

Chemical Name:tert-butyl 4-(methylthio)-5-oxo-2-phenyl-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate
CAS No.:1345013-95-7
Molecular Formula:C₂₀H₂₂N₂O₃S
Molecular Weight:370.472
Hs Code.:

Synonyms:tert-butyl 4-(methylthio)-5-oxo-2-phenyl-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate

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Chemical Property of tert-butyl 4-(methylthio)-5-oxo-2-phenyl-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate

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Technology Process of tert-butyl 4-(methylthio)-5-oxo-2-phenyl-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate

There total 4 articles about tert-butyl 4-(methylthio)-5-oxo-2-phenyl-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 1345013-92-4
tert-butyl 3-[bis(methylthio)methylene]-2,4-dioxopiperidine-1-carboxylate

: 98-86-2
acetophenone

: 1345013-95-7
tert-butyl 4-(methylthio)-5-oxo-2-phenyl-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate

Guidance literature:: tert-butyl 3-[bis(methylthio)methylene]-2,4-dioxopiperidine-1-carboxylate; acetophenone; With potassium tert-butylate; In tetrahydrofuran; dimethyl sulfoxide; for 2.5h;

With ammonium acetate; acetic acid; In tetrahydrofuran; dimethyl sulfoxide; at 90 ℃; for 2h;

Reference yield:

: C₂₀H₂₃NO₅S

: 1345013-95-7
tert-butyl 4-(methylthio)-5-oxo-2-phenyl-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate

Guidance literature:: With ammonium acetate; acetic acid; In tetrahydrofuran; dimethyl sulfoxide; at 90 ℃; for 2h;
DOI:10.1016/j.tetlet.2013.06.016

Reference yield:

: 1345013-92-4
tert-butyl 3-[bis(methylthio)methylene]-2,4-dioxopiperidine-1-carboxylate

: 1345013-95-7
tert-butyl 4-(methylthio)-5-oxo-2-phenyl-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium tert-butylate / dimethyl sulfoxide; tetrahydrofuran / 2 h / 25 °C

2: ammonium acetate; acetic acid / dimethyl sulfoxide; tetrahydrofuran / 2 h / 90 °C

With potassium tert-butylate; ammonium acetate; acetic acid; In tetrahydrofuran; dimethyl sulfoxide;
DOI:10.1016/j.tetlet.2013.06.016