6-hydroxy-2-(N-4-phenylbenzenecarbonyl)amino-N-(4-chlorobenzyl)hexaneamide

Base Information

Chemical Name:6-hydroxy-2-(N-4-phenylbenzenecarbonyl)amino-N-(4-chlorobenzyl)hexaneamide
CAS No.:1456906-68-5
Molecular Formula:C₂₆H₂₇ClN₂O₃
Molecular Weight:450.965
Hs Code.:

Synonyms:6-hydroxy-2-(N-4-phenylbenzenecarbonyl)amino-N-(4-chlorobenzyl)hexaneamide

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Chemical Property of 6-hydroxy-2-(N-4-phenylbenzenecarbonyl)amino-N-(4-chlorobenzyl)hexaneamide

Chemical Property:

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Technology Process of 6-hydroxy-2-(N-4-phenylbenzenecarbonyl)amino-N-(4-chlorobenzyl)hexaneamide

There total 6 articles about 6-hydroxy-2-(N-4-phenylbenzenecarbonyl)amino-N-(4-chlorobenzyl)hexaneamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1456906-65-2
6-amino-2-(n-4-phenylbenzenecarbonyl)amino-N-(4-chlorobenzyl)hexaneamide hydrochloride

: 1456906-68-5
6-hydroxy-2-(N-4-phenylbenzenecarbonyl)amino-N-(4-chlorobenzyl)hexaneamide

Guidance literature:: With hydrogenchloride; acetic acid; sodium nitrite; In water; acetonitrile; at 0 - 20 ℃;
DOI:10.1002/anie.201303999

Reference yield:

: 71989-26-9
Fmoc-Lys(tert-butoxycarbonyl)

: 1456906-68-5
6-hydroxy-2-(N-4-phenylbenzenecarbonyl)amino-N-(4-chlorobenzyl)hexaneamide

Guidance literature:: Multi-step reaction with 5 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 0 - 20 °C

2: piperidine / dichloromethane / 2 h / 20 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 0 - 20 °C

4: hydrogenchloride / 1,4-dioxane; dichloromethane / 2.5 h / 0 - 20 °C

5: hydrogenchloride; sodium nitrite; acetic acid / water; acetonitrile / 0 - 20 °C

With piperidine; hydrogenchloride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium nitrite; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/anie.201303999

Reference yield:

: 104-86-9
4-chlorobenzylamine

: 1456906-68-5
6-hydroxy-2-(N-4-phenylbenzenecarbonyl)amino-N-(4-chlorobenzyl)hexaneamide

Guidance literature:: Multi-step reaction with 5 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 0 - 20 °C

2: piperidine / dichloromethane / 2 h / 20 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 0 - 20 °C

4: hydrogenchloride / 1,4-dioxane; dichloromethane / 2.5 h / 0 - 20 °C

5: hydrogenchloride; sodium nitrite; acetic acid / water; acetonitrile / 0 - 20 °C

With piperidine; hydrogenchloride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium nitrite; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/anie.201303999