(2S,3S)-2-methyl-3-(4-methoxyphenylamino)-3-(4-nitrophenyl)-propan-1-ol

Base Information

Chemical Name:(2S,3S)-2-methyl-3-(4-methoxyphenylamino)-3-(4-nitrophenyl)-propan-1-ol
CAS No.:605683-33-8
Molecular Formula:C₁₇H₂₀N₂O₄
Molecular Weight:316.357
Hs Code.:

Synonyms:(2S,3S)-2-methyl-3-(4-methoxyphenylamino)-3-(4-nitrophenyl)-propan-1-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3S)-2-methyl-3-(4-methoxyphenylamino)-3-(4-nitrophenyl)-propan-1-ol

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Technology Process of (2S,3S)-2-methyl-3-(4-methoxyphenylamino)-3-(4-nitrophenyl)-propan-1-ol

There total 12 articles about (2S,3S)-2-methyl-3-(4-methoxyphenylamino)-3-(4-nitrophenyl)-propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 555-16-8
4-nitrobenzaldehdye

: 104-94-9
4-methoxy-aniline

: 123-38-6
propionaldehyde

: 605683-33-8
(2S,3S)-2-methyl-3-(4-methoxyphenylamino)-3-(4-nitrophenyl)-propan-1-ol

Guidance literature:: 4-nitrobenzaldehdye; 4-methoxy-aniline; propionaldehyde; With L-proline; In N,N-dimethyl-formamide; at -20 ℃;

With sodium tetrahydroborate; In diethyl ether; N,N-dimethyl-formamide; at 0 ℃; for 0.166667h;
DOI:10.1021/jo0347359

Reference yield:

: 708271-54-9
(2S,3S)-3-(4-Methoxy-phenylamino)-2-methyl-3-(4-nitro-phenyl)-propionaldehyde

: 605683-33-8
(2S,3S)-2-methyl-3-(4-methoxyphenylamino)-3-(4-nitrophenyl)-propan-1-ol

Guidance literature:: With sodium tetrahydroborate; In methanol; at 0 ℃;
DOI:10.1002/anie.200351813

Reference yield:

: 555-16-8
4-nitrobenzaldehdye

: 605683-33-8
(2S,3S)-2-methyl-3-(4-methoxyphenylamino)-3-(4-nitrophenyl)-propan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: (S)-proline / dimethylformamide / 4 °C

2: NaBH₄ / diethyl ether / 0.17 h / 0 °C

With sodium tetrahydroborate; L-proline; In diethyl ether; N,N-dimethyl-formamide; 1: cross-Mannich reaction;
DOI:10.1002/chem.200305646