1-(4-chlorophenyl)-2-(4-methoxyphenyl)-4,5-diphenyl-1H-imidazole

Base Information

• Chemical Name: 1-(4-chlorophenyl)-2-(4-methoxyphenyl)-4,5-diphenyl-1H-imidazole
• CAS No.: 1589550-51-5
• Molecular Formula: C₂₈H₂₁ClN₂O
• Molecular Weight: 436.941
• Mol file: 1589550-51-5.mol

Synonyms:1-(4-chlorophenyl)-2-(4-methoxyphenyl)-4,5-diphenyl-1H-imidazole

Chemical Property of 1-(4-chlorophenyl)-2-(4-methoxyphenyl)-4,5-diphenyl-1H-imidazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 1-(4-chlorophenyl)-2-(4-methoxyphenyl)-4,5-diphenyl-1H-imidazole

There total 3 articles about 1-(4-chlorophenyl)-2-(4-methoxyphenyl)-4,5-diphenyl-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-chloro-aniline (106-47-8) + 4-methoxy-benzaldehyde (123-11-5) + benzil (134-81-6) → 1-(4-chlorophenyl)-2-(4-methoxyphenyl)-4,5-diphenyl-1H-imidazole (1589550-51-5)

Guidance literature:

With ammonium acetate; citric acid; In neat (no solvent); at 130 ℃; for 7h; Reagent/catalyst;

DOI:10.1007/s11164-014-1583-z

Reference yield: 90.0%

ammonium acetate (631-61-8,92206-38-7) + 4-chloro-aniline (106-47-8) + 4-methoxy-benzaldehyde (123-11-5) + benzil (134-81-6) → 1-(4-chlorophenyl)-2-(4-methoxyphenyl)-4,5-diphenyl-1H-imidazole (1589550-51-5)

Guidance literature:

With cerium(IV) oxide; In methanol; for 12h; Reflux;

DOI:10.1007/s11164-017-2886-7

Reference yield: 86.0%

4-Methoxymandelic acid (20714-90-3) + 4-chloro-aniline (106-47-8) + diphenyl acetylene (501-65-5) → 1-(4-chlorophenyl)-2-(4-methoxyphenyl)-4,5-diphenyl-1H-imidazole (1589550-51-5)

Guidance literature:

4-Methoxymandelic acid; diphenyl acetylene; With bismuth(III) nitrate; cerium (IV) sulfate tetrahydrate; palladium diacetate; Trimethylacetic acid; In water; dimethyl sulfoxide; at 120 ℃; for 2h; Schlenk technique;

4-chloro-aniline; With ammonium acetate; In water; dimethyl sulfoxide; at 120 ℃; for 10h; Schlenk technique;

DOI:10.1055/s-0037-1611835

upstream raw materials:

4-chloro-aniline

4-methoxy-benzaldehyde

benzil

ammonium acetate