2-deutero-3-(4-methoxyphenyl)-5-(2-[4-methoxyphenyl]-1,3-dioxolan-2-yl)pyrazine

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Chemical Name:2-deutero-3-(4-methoxyphenyl)-5-(2-[4-methoxyphenyl]-1,3-dioxolan-2-yl)pyrazine
CAS No.:850221-76-0
Molecular Formula:C₂₁H₂₀N₂O₄
Molecular Weight:365.393
Hs Code.:

Synonyms:2-deutero-3-(4-methoxyphenyl)-5-(2-[4-methoxyphenyl]-1,3-dioxolan-2-yl)pyrazine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-deutero-3-(4-methoxyphenyl)-5-(2-[4-methoxyphenyl]-1,3-dioxolan-2-yl)pyrazine

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Technology Process of 2-deutero-3-(4-methoxyphenyl)-5-(2-[4-methoxyphenyl]-1,3-dioxolan-2-yl)pyrazine

There total 4 articles about 2-deutero-3-(4-methoxyphenyl)-5-(2-[4-methoxyphenyl]-1,3-dioxolan-2-yl)pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 850221-75-9
3-chloro-2-deutero-5-(2-[4-methoxyphenyl]-1,3-dioxolan-2-yl)pyrazine

: 5720-07-0
4-methoxyphenylboronic acid

: 850221-76-0
2-deutero-3-(4-methoxyphenyl)-5-(2-[4-methoxyphenyl]-1,3-dioxolan-2-yl)pyrazine

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; toluene; for 8h; Heating;
DOI:10.1021/jo0478196

Reference yield:

: 100-07-2
4-methoxy-benzoyl chloride

: 850221-76-0
2-deutero-3-(4-methoxyphenyl)-5-(2-[4-methoxyphenyl]-1,3-dioxolan-2-yl)pyrazine

Guidance literature:: Multi-step reaction with 4 steps

1.1: 70 percent / Pd(PPh₃)4 / toluene / 12 h / Heating

2.1: 98 percent / APTS / toluene / 8 h / Heating

3.1: n-butyllithium; 2,2,6,6-tetramethylpiperidine / tetrahydrofuran; hexane / 0.5 h / -78 °C

3.2: 98 percent / EtOD / tetrahydrofuran; hexane / 0.08 h / -78 °C

4.1: 90 percent / aq. K₂CO₃ / Pd(PPh₃)4 / toluene; ethanol / 8 h / Heating

With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; potassium carbonate; 8-aminopyrene-1,3,6-trisulfonic acid, trisodium salt; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; hexane; toluene; 1.1: Stille reaction / 4.1: Suzuki reaction;
DOI:10.1021/jo0478196

Reference yield:

: 850221-69-1
2-chloro-6-(1-oxo-[4-methoxyphenyl]methyl)pyrazine

: 850221-76-0
2-deutero-3-(4-methoxyphenyl)-5-(2-[4-methoxyphenyl]-1,3-dioxolan-2-yl)pyrazine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 98 percent / APTS / toluene / 8 h / Heating

2.1: n-butyllithium; 2,2,6,6-tetramethylpiperidine / tetrahydrofuran; hexane / 0.5 h / -78 °C

2.2: 98 percent / EtOD / tetrahydrofuran; hexane / 0.08 h / -78 °C

3.1: 90 percent / aq. K₂CO₃ / Pd(PPh₃)4 / toluene; ethanol / 8 h / Heating

With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; potassium carbonate; 8-aminopyrene-1,3,6-trisulfonic acid, trisodium salt; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; hexane; toluene; 3.1: Suzuki reaction;
DOI:10.1021/jo0478196