2-(3-methanesulfonyloxymethyl-4-methoxy-phenyl)-5-methyl-2H-pyrazole-3-carboxylic acid ethyl ester

Base Information

• Chemical Name: 2-(3-methanesulfonyloxymethyl-4-methoxy-phenyl)-5-methyl-2H-pyrazole-3-carboxylic acid ethyl ester
• CAS No.: 637318-37-7
• Molecular Formula: C₁₆H₂₀N₂O₆S
• Molecular Weight: 368.411
• Mol file: 637318-37-7.mol

Synonyms:2-(3-methanesulfonyloxymethyl-4-methoxy-phenyl)-5-methyl-2H-pyrazole-3-carboxylic acid ethyl ester

Chemical Property of 2-(3-methanesulfonyloxymethyl-4-methoxy-phenyl)-5-methyl-2H-pyrazole-3-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3-methanesulfonyloxymethyl-4-methoxy-phenyl)-5-methyl-2H-pyrazole-3-carboxylic acid ethyl ester

There total 7 articles about 2-(3-methanesulfonyloxymethyl-4-methoxy-phenyl)-5-methyl-2H-pyrazole-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanesulfonyl chloride (124-63-0) + ethyl 1-(3-hydroxymethyl-4-methoxyphenyl)-3-methyl-1H-pyrazole-5-carboxylate (637318-35-5) → 2-(3-methanesulfonyloxymethyl-4-methoxy-phenyl)-5-methyl-2H-pyrazole-3-carboxylic acid ethyl ester (637318-37-7)

Guidance literature:

With triethylamine; In chloroform; at 0 - 20 ℃; for 18h;

DOI:10.1021/jm030212h

Reference yield:

3-amino-6-methoxy-benzoic acid (3403-47-2) → 2-(3-methanesulfonyloxymethyl-4-methoxy-phenyl)-5-methyl-2H-pyrazole-3-carboxylic acid ethyl ester (637318-37-7)

Guidance literature:

Multi-step reaction with 5 steps

1.1: HCl; NaNO₂ / H₂O / 0.5 h / 0 °C

1.2: SnCl₂*2H₂O; HCl / H₂O / 0.25 h / 0 °C

2.1: acetonitrile; H₂O / 3 h / Heating

3.1: N-methylmorpholine / tetrahydrofuran / 0.33 h / 0 °C

4.1: 0.9 g / NaBH₄ / tetrahydrofuran; H₂O / 4 h / 0 - 20 °C

5.1: 0.72 g / Et₃N / CHCl₃ / 18 h / 0 - 20 °C

With 4-methyl-morpholine; hydrogenchloride; sodium tetrahydroborate; triethylamine; sodium nitrite; In tetrahydrofuran; chloroform; water; acetonitrile;

DOI:10.1021/jm030212h

Reference yield:

ethyl 2,4-diketopentanoate (615-79-2) → 2-(3-methanesulfonyloxymethyl-4-methoxy-phenyl)-5-methyl-2H-pyrazole-3-carboxylic acid ethyl ester (637318-37-7)

Guidance literature:

Multi-step reaction with 5 steps

1: 40 percent / 3A molecular sieves / ethanol / 18 h

2: acetonitrile; H₂O / 3 h / Heating

3: N-methylmorpholine / tetrahydrofuran / 0.33 h / 0 °C

4: 0.9 g / NaBH₄ / tetrahydrofuran; H₂O / 4 h / 0 - 20 °C

5: 0.72 g / Et₃N / CHCl₃ / 18 h / 0 - 20 °C

With 4-methyl-morpholine; sodium tetrahydroborate; 3 A molecular sieve; triethylamine; In tetrahydrofuran; ethanol; chloroform; water; acetonitrile;

DOI:10.1021/jm030212h

upstream raw materials:

methanesulfonyl chloride

ethyl 1-(3-hydroxymethyl-4-methoxyphenyl)-3-methyl-1H-pyrazole-5-carboxylate

3-amino-6-methoxy-benzoic acid

ethyl 2,4-diketopentanoate

Downstream raw materials:

2-(3-aminomethyl-4-methoxy-phenyl)-5-methyl-2H-pyrazole-3-carboxylic acid (2'-tert-butylsulfamoyl-biphenyl-4-yl)-amide

1-(3-azidomethyl-4-methoxyphenyl)-3-methyl-1H-pyrazole-5-(2'-(N-t-butylaminosulfonyl)-[1,1']-biphen-4-yl)carboxamide

1-(3-azidomethyl-4-methoxyphenyl)-3-methyl-1H-pyrazole-5-carboxylic acid

2-(3-azidomethyl-4-methoxy-phenyl)-5-methyl-2H-pyrazole-3-carboxylic acid ethyl ester