N-((2S,3S,4R)-1,3-bis(benzyloxy)-5-(tert-butyldimethylsilyloxy)-4-hydroxypentan-2-yl)-4-methylbenzenesulfonamide

Base Information

Chemical Name:N-((2S,3S,4R)-1,3-bis(benzyloxy)-5-(tert-butyldimethylsilyloxy)-4-hydroxypentan-2-yl)-4-methylbenzenesulfonamide
CAS No.:221216-64-4
Molecular Formula:C₃₂H₄₅NO₆SSi
Molecular Weight:599.864
Hs Code.:

Synonyms:N-((2S,3S,4R)-1,3-bis(benzyloxy)-5-(tert-butyldimethylsilyloxy)-4-hydroxypentan-2-yl)-4-methylbenzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-((2S,3S,4R)-1,3-bis(benzyloxy)-5-(tert-butyldimethylsilyloxy)-4-hydroxypentan-2-yl)-4-methylbenzenesulfonamide

Chemical Property:

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Technology Process of N-((2S,3S,4R)-1,3-bis(benzyloxy)-5-(tert-butyldimethylsilyloxy)-4-hydroxypentan-2-yl)-4-methylbenzenesulfonamide

There total 11 articles about N-((2S,3S,4R)-1,3-bis(benzyloxy)-5-(tert-butyldimethylsilyloxy)-4-hydroxypentan-2-yl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 221216-58-6
N-((1S,2S,3R)-2-Benzyloxy-1-benzyloxymethyl-3,4-dihydroxy-butyl)-4-methyl-benzenesulfonamide

: 221216-64-4
N-((2S,3S,4R)-1,3-bis(benzyloxy)-5-(tert-butyldimethylsilyloxy)-4-hydroxypentan-2-yl)-4-methylbenzenesulfonamide

Guidance literature:: With dmap; triethylamine; In dichloromethane; Yield given;
DOI:10.1016/S0040-4039(98)02345-4

Reference yield:

: 221276-73-9
(1S,2S)-2-Azido-3-benzyloxy-1-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-propan-1-ol

: 221216-64-4
N-((2S,3S,4R)-1,3-bis(benzyloxy)-5-(tert-butyldimethylsilyloxy)-4-hydroxypentan-2-yl)-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: 87 percent / NaH, Bu₄NI / tetrahydrofuran / Heating

2: LiAlH₄ / tetrahydrofuran

3: Et₃N / CH₂Cl₂

4: 95 percent / 2N HCl / methanol / 40 °C

5: DMAP, Et₃N / CH₂Cl₂

With hydrogenchloride; dmap; lithium aluminium tetrahydride; tetra-(n-butyl)ammonium iodide; sodium hydride; triethylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0040-4039(98)02345-4

Reference yield:

: (1S,2S)-2-Benzyloxy-1-benzyloxymethyl-2-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-ethylamine

: 221216-64-4
N-((2S,3S,4R)-1,3-bis(benzyloxy)-5-(tert-butyldimethylsilyloxy)-4-hydroxypentan-2-yl)-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / CH₂Cl₂

2: 95 percent / 2N HCl / methanol / 40 °C

3: DMAP, Et₃N / CH₂Cl₂

With hydrogenchloride; dmap; triethylamine; In methanol; dichloromethane;
DOI:10.1016/S0040-4039(98)02345-4