(R)-4-((1S,2S)-2-azido-1,3-bis(benzyloxy)propyl)-2,2-dimethyl-1,3-dioxolane

Base Information

Chemical Name:(R)-4-((1S,2S)-2-azido-1,3-bis(benzyloxy)propyl)-2,2-dimethyl-1,3-dioxolane
CAS No.:221216-48-4
Molecular Formula:C₂₂H₂₇N₃O₄
Molecular Weight:397.474
Hs Code.:

Synonyms:(R)-4-((1S,2S)-2-azido-1,3-bis(benzyloxy)propyl)-2,2-dimethyl-1,3-dioxolane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-4-((1S,2S)-2-azido-1,3-bis(benzyloxy)propyl)-2,2-dimethyl-1,3-dioxolane

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Technology Process of (R)-4-((1S,2S)-2-azido-1,3-bis(benzyloxy)propyl)-2,2-dimethyl-1,3-dioxolane

There total 7 articles about (R)-4-((1S,2S)-2-azido-1,3-bis(benzyloxy)propyl)-2,2-dimethyl-1,3-dioxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 100-39-0
benzyl bromide

: 221276-73-9
(1S,2S)-2-Azido-3-benzyloxy-1-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-propan-1-ol

: 221216-48-4
(R)-4-((1S,2S)-2-azido-1,3-bis(benzyloxy)propyl)-2,2-dimethyl-1,3-dioxolane

Guidance literature:: With tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; Heating;
DOI:10.1016/S0040-4039(98)02345-4

Reference yield:

: (R)-4-((2S,3S)-3-Benzyloxymethyl-oxiranyl)-2,2-dimethyl-[1,3]dioxolane

: 221216-48-4
(R)-4-((1S,2S)-2-azido-1,3-bis(benzyloxy)propyl)-2,2-dimethyl-1,3-dioxolane

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / NaN₃, NH₄Cl / various solvent(s) / Heating

2: 87 percent / NaH, Bu₄NI / tetrahydrofuran / Heating

With sodium azide; tetra-(n-butyl)ammonium iodide; sodium hydride; ammonium chloride; In tetrahydrofuran;
DOI:10.1016/S0040-4039(98)02345-4

Reference yield:

: 922-65-6
divinylcarbinol

: 221216-48-4
(R)-4-((1S,2S)-2-azido-1,3-bis(benzyloxy)propyl)-2,2-dimethyl-1,3-dioxolane

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) TBHP, D-(-)-DIPT, Ti(O-iso-Pr)4, 4 Angstroem molecular sieves, 2.) 0.5N NaOH / 1.) CH₂Cl₂, -20 deg C, 10 d, 2.) -10 deg C

2: 87 percent / NaH, Bu₄NI / tetrahydrofuran

3: DHQ-PYR, K₂2(OH)4>, K₂CO₃, K₃ / 2-methyl-propan-2-ol; H₂O

4: PTS / CH₂Cl₂

5: 87 percent / NaN₃, NH₄Cl / various solvent(s) / Heating

6: 87 percent / NaH, Bu₄NI / tetrahydrofuran / Heating

With titanium(IV) isopropylate; tert.-butylhydroperoxide; sodium hydroxide; sodium azide; K2; 4 A molecular sieve; pyridinium p-toluenesulfonate; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium carbonate; D-(-)-diisopropyl tartrate; ammonium chloride; potassium hexacyanoferrate(III); In tetrahydrofuran; dichloromethane; water; tert-butyl alcohol;
DOI:10.1016/S0040-4039(98)02345-4