(-)-[(1R,2R)-2-methylamino-1-phenylpropyl]-diphenylphosphine

Base Information

• Chemical Name: (-)-[(1R,2R)-2-methylamino-1-phenylpropyl]-diphenylphosphine
• CAS No.: 341968-72-7
• Molecular Formula: C₂₂H₂₄NP
• Molecular Weight: 333.413
• Mol file: 341968-72-7.mol

Synonyms:(-)-[(1R,2R)-2-methylamino-1-phenylpropyl]-diphenylphosphine

Chemical Property of (-)-[(1R,2R)-2-methylamino-1-phenylpropyl]-diphenylphosphine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (-)-[(1R,2R)-2-methylamino-1-phenylpropyl]-diphenylphosphine

There total 2 articles about (-)-[(1R,2R)-2-methylamino-1-phenylpropyl]-diphenylphosphine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

(+)-cis-(2R,3S)-1,2-dimethyl-3-phenylaziridin (2242-90-2) + diphenylphosphane (829-85-6) → (-)-[(1R,2R)-2-methylamino-1-phenylpropyl]-diphenylphosphine (341968-72-7)

Guidance literature:

With boron trifluoride diethyl etherate; In chloroform; Heating;

DOI:10.1016/S0022-328X(00)00520-9

Reference yield:

(1R,2R)-pseudoephedrine (321-97-1,7009-81-6,90-83-5,6912-63-6) → (-)-[(1R,2R)-2-methylamino-1-phenylpropyl]-diphenylphosphine (341968-72-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 57 percent / PPh₃; Br₂; triethylamine / acetonitrile

2: 82 percent / Et₂O*BF₃ / CHCl₃ / Heating

With boron trifluoride diethyl etherate; bromine; triethylamine; triphenylphosphine; In chloroform; acetonitrile;

DOI:10.1016/S0022-328X(00)00520-9

Reference yield:

silver tetrafluoroborate (14104-20-2) + chloro(1,5-cyclooctadiene)rhodium(I) dimer + (-)-[(1R,2R)-2-methylamino-1-phenylpropyl]-diphenylphosphine (341968-72-7) → [Rh(C8H12)((C6H5)2PCH(C6H5)CH(CH3)NHCH3)](1+)*BF4(1-)=[Rh(C8H12)((C6H5)2PCH(C6H5)CH(CH3)NHCH3)]BF4 + [Rh(C8H12)((C6H5)2PCH(C6H5)CH(CH3)NHCH3)](1+)*BF4(1-)=[Rh(C8H12)((C6H5)2PCH(C6H5)CH(CH3)NHCH3)]BF4

Guidance literature:

In tetrahydrofuran; byproducts: AgCl; (N2); addn. of a soln. of phosphine in THF to a soln. of rhodium complexin THF dropwise, stirring overnight, addn. of silver salt; filtration, evapn.;

DOI:10.1016/S0022-328X(00)00520-9

upstream raw materials:

(+)-cis-(2R,3S)-1,2-dimethyl-3-phenylaziridin

diphenylphosphane

(1R,2R)-pseudoephedrine