methyl α-methylene-β-[(p-toluenesulfonyl)amino]-3-(2-pyridyl)propionate

Base Information

Chemical Name:methyl α-methylene-β-[(p-toluenesulfonyl)amino]-3-(2-pyridyl)propionate
CAS No.:364364-55-6
Molecular Formula:C₁₇H₁₈N₂O₄S
Molecular Weight:346.407
Hs Code.:

Synonyms:methyl α-methylene-β-[(p-toluenesulfonyl)amino]-3-(2-pyridyl)propionate

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Chemical Property of methyl α-methylene-β-[(p-toluenesulfonyl)amino]-3-(2-pyridyl)propionate

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Technology Process of methyl α-methylene-β-[(p-toluenesulfonyl)amino]-3-(2-pyridyl)propionate

There total 1 articles about methyl α-methylene-β-[(p-toluenesulfonyl)amino]-3-(2-pyridyl)propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1121-60-4
pyridine-2-carbaldehyde

: 70-55-3
toluene-4-sulfonamide

: 292638-85-8,9003-21-8,96-33-3
acrylic acid methyl ester

: 118488-74-7
2-(hydroxy-pyridin-2-yl-methyl)-acrylic acid methyl ester

: 364364-55-6
methyl α-methylene-β-[(p-toluenesulfonyl)amino]-3-(2-pyridyl)propionate

Guidance literature:: With 4 Angstroem MS; 3-quinuclidinol; titanium(IV) isopropylate; In isopropyl alcohol; at 20 ℃; for 6h;
DOI:10.1021/jo0163952

Reference yield:

: 364364-55-6
methyl α-methylene-β-[(p-toluenesulfonyl)amino]-3-(2-pyridyl)propionate

: 2-pyridin-2-yl-1-(toluene-4-sulfonyl)-2,5-dihydro-1H-pyrrole-3-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: K₂CO₃ / dimethylformamide / 20 °C

2: 95 percent / (Cy)3PRuCl₂(=CHPh)(1,3-(Mes)2imidazolidin-2-yl) / CH₂Cl₂ / 0.02 h / 100 °C / microwave irradiation

With potassium carbonate; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2004.02.100