1-(2-Methoxybenzoyl)pyrrolidine, 97%

Base Information

• Chemical Name: 1-(2-Methoxybenzoyl)pyrrolidine, 97%
• CAS No.: 120173-04-8
• Molecular Formula: C₁₂H₁₅NO₂
• Molecular Weight: 205.257
• Mol file: 120173-04-8.mol

Synonyms:(2-methoxyphenyl)(pyrrolidin-1-yl)methanone

Chemical Property of 1-(2-Methoxybenzoyl)pyrrolidine, 97%

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

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Technology Process of 1-(2-Methoxybenzoyl)pyrrolidine, 97%

There total 7 articles about 1-(2-Methoxybenzoyl)pyrrolidine, 97% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

pyrrolidine (123-75-1) + 2-methoxybenzoic acid methyl ester (606-45-1) → (2-methoxyphenyl)(pyrrolidin-1-yl)methanone (120173-04-8)

Guidance literature:

In acetonitrile; at 35 ℃; for 96h; under 6000480 Torr;

Reference yield: 98.0%

pyrrolidine (123-75-1) + (1H-benzo[d][1,2,3]triazol-1-yl)(2-methoxyphenyl)methanone (306990-93-2) → (2-methoxyphenyl)(pyrrolidin-1-yl)methanone (120173-04-8)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 4h;

DOI:10.1021/jo000792f

Reference yield: 56.0%

pyrrolidine (123-75-1) + 2-Methoxybenzoyl chloride (21615-34-9) → (2-methoxyphenyl)(pyrrolidin-1-yl)methanone (120173-04-8)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1002/chem.202004840

upstream raw materials:

pyrrolidine

2-methoxybenzoic acid methyl ester

(1H-benzo[d][1,2,3]triazol-1-yl)(2-methoxyphenyl)methanone

2-Methoxybenzoic acid

Downstream raw materials:

C₁₂H₁₇NO

(2-methoxy-6-(3-methylbut-2-enyl)phenyl)(pyrrolidin-1-yl)methanone

2-(3'-azidopropyl)-2-(pyrrolidinecarbon-1'-yl)cyclohex-3-enone

(1-allyl-2-methoxy-cyclohexa-2,5-dienyl)-pyrrolidin-1-yl-methanone

Refernces

Sequential Birch reduction-allylation and Cope rearrangement of o-anisic acid derivatives

10.1016/j.tetlet.2004.09.025

The study presents a novel approach for constructing quaternary centers on cycloalkane rings, which is a significant challenge in synthetic chemistry. The researchers utilized a combination of Birch reduction-allylation and Cope rearrangement on o-anisic acid derivatives to synthesize 2-acyl-3-cyclohexenone derivatives. They successfully generated rearrangement substrates and achieved high yields of 2-cyclohexenone products through thermal equilibration in 1,2-dichlorobenzene. Notably, the Cope rearrangement of a specific substrate resulted in the formation of a new quaternary center with excellent yield, marking the first example of such synthesis on a cycloalkenone ring via Cope rearrangement. This method could serve as a powerful tool for creating substituted 2-cyclohexenones, offering a potentially versatile synthetic intermediate with potential for 1,3-chirality transfer and access to enantiomerically pure products.

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