(E)-2-(N-(tertbutoxycarbonyl)-N-ethylamino)-5-(2,6-difluorostyryl)pyridine

Base Information

Chemical Name:(E)-2-(N-(tertbutoxycarbonyl)-N-ethylamino)-5-(2,6-difluorostyryl)pyridine
CAS No.:1620092-99-0
Molecular Formula:C₂₀H₂₂F₂N₂O₂
Molecular Weight:360.404
Hs Code.:

Synonyms:(E)-2-(N-(tertbutoxycarbonyl)-N-ethylamino)-5-(2,6-difluorostyryl)pyridine

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Chemical Property of (E)-2-(N-(tertbutoxycarbonyl)-N-ethylamino)-5-(2,6-difluorostyryl)pyridine

Chemical Property:

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Technology Process of (E)-2-(N-(tertbutoxycarbonyl)-N-ethylamino)-5-(2,6-difluorostyryl)pyridine

There total 3 articles about (E)-2-(N-(tertbutoxycarbonyl)-N-ethylamino)-5-(2,6-difluorostyryl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1620092-98-9
(E)-2-(tert-butoxycarbonylamino)-5-(2,6-difluorostyryl)pyridine

: 75-03-6
ethyl iodide

: 1620092-99-0
(E)-2-(N-(tertbutoxycarbonyl)-N-ethylamino)-5-(2,6-difluorostyryl)pyridine

Guidance literature:: (E)-2-(tert-butoxycarbonylamino)-5-(2,6-difluorostyryl)pyridine; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.333333h;

ethyl iodide; In N,N-dimethyl-formamide; at 5 - 25 ℃; for 12.5h;
DOI:10.1021/jm5004864

Reference yield:

: diethyl 2,6-difluorobenzylphosphonate

: 1620092-99-0
(E)-2-(N-(tertbutoxycarbonyl)-N-ethylamino)-5-(2,6-difluorostyryl)pyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / hexane; N,N-dimethyl-formamide / 0.25 h / 0 °C

1.2: 12 h / 0 - 25 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C

2.2: 12.5 h / 5 - 25 °C

With sodium hydride; In hexane; N,N-dimethyl-formamide; 1.1: |Horner-Wadsworth-Emmons Olefination / 1.2: |Horner-Wadsworth-Emmons Olefination / 2.1: |Horner-Wadsworth-Emmons Olefination / 2.2: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1021/jm5004864

Reference yield:

: 199296-40-7
2-(tert-butyloxycarbonyl)-aminopyridine-5-carboxaldehyde

: 1620092-99-0
(E)-2-(N-(tertbutoxycarbonyl)-N-ethylamino)-5-(2,6-difluorostyryl)pyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / hexane; N,N-dimethyl-formamide / 0.25 h / 0 °C

1.2: 12 h / 0 - 25 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C

2.2: 12.5 h / 5 - 25 °C

With sodium hydride; In hexane; N,N-dimethyl-formamide; 1.1: |Horner-Wadsworth-Emmons Olefination / 1.2: |Horner-Wadsworth-Emmons Olefination / 2.1: |Horner-Wadsworth-Emmons Olefination / 2.2: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1021/jm5004864