C₁₃H₁₅NO₄

Base Information

• Chemical Name: C₁₃H₁₅NO₄
• CAS No.: 1584725-20-1
• Molecular Formula: C₁₃H₁₅NO₄
• Molecular Weight: 249.266
• Mol file: 1584725-20-1.mol

Synonyms:C₁₃H₁₅NO₄

Chemical Property of C₁₃H₁₅NO₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₃H₁₅NO₄

There total 2 articles about C₁₃H₁₅NO₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzaldehyde (100-52-7) + dimethyl (R)-2-aminobutanedioate hydrochloride (14358-33-9,32213-95-9,69630-50-8) → C13H15NO4 (1584725-20-1)

Guidance literature:

With sodium sulfate; triethylamine; In dichloromethane; at 20 ℃; for 16h;

DOI:10.1021/jm401707t

Reference yield:

methanol (67-56-1) + (2R)-aspartic acid (1783-96-6,25608-40-6,27881-03-4,32505-46-7,52526-39-3) + benzaldehyde (100-52-7) → C13H15NO4 (1584725-20-1)

Guidance literature:

methanol; (2R)-aspartic acid; With chloro-trimethyl-silane;

benzaldehyde;

DOI:10.1039/c7ob01530e

Reference yield:

C13H15NO4 (1584725-20-1) → Dimethyl D-N-benzylaspartate (155069-71-9)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 - 20 ℃; for 0.75h;

DOI:10.1021/jm401707t

upstream raw materials:

benzaldehyde

dimethyl (R)-2-aminobutanedioate hydrochloride

methanol

(2R)-aspartic acid

Downstream raw materials:

methyl (R)-2-[1-benzyl-4-(cyclohexylmethyl)-3,6-dioxopiperazin-2-yl]acetate

Dimethyl D-N-benzylaspartate

(R)-2-[1-benzyl-4-(cyclohexylmethyl)piperazin-2-yl]ethanol

(R)-methyl 2-(1-benzyl-3,6-dioxopiperazin-2-yl)acetate

Refernces

• 1、 Wittig, Christian,Schepmann, Dirk,Soeberdt, Michael,Daniliuc, Constantin G.,Wünsch, Bernhard. "Stereoselective synthesis of conformationally restricted KOR agonists based on the 2,5-diazabicyclo[2.2.2]octane scaffold". . p. 6520 - 6540. Retrieved 2017/08/16.