methyl (S)-3-(((R)-tert-butylsulfinyl)amino)-3-(2-fluoro-5-nitrophenyl)butanoate

Base Information

Chemical Name:methyl (S)-3-(((R)-tert-butylsulfinyl)amino)-3-(2-fluoro-5-nitrophenyl)butanoate
CAS No.:1254199-42-2
Molecular Formula:C₁₅H₂₁FN₂O₅S
Molecular Weight:360.407
Hs Code.:

Synonyms:methyl (S)-3-(((R)-tert-butylsulfinyl)amino)-3-(2-fluoro-5-nitrophenyl)butanoate

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Chemical Property of methyl (S)-3-(((R)-tert-butylsulfinyl)amino)-3-(2-fluoro-5-nitrophenyl)butanoate

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Technology Process of methyl (S)-3-(((R)-tert-butylsulfinyl)amino)-3-(2-fluoro-5-nitrophenyl)butanoate

There total 5 articles about methyl (S)-3-(((R)-tert-butylsulfinyl)amino)-3-(2-fluoro-5-nitrophenyl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 79-20-9
acetic acid methyl ester

: 1075230-62-4
(R)-2-methylpropane-2-sulfinic acid [1-(2-fluoro-5-nitrophenyl)-(E)-ethylidene]amide

: 1254199-42-2
methyl (S)-3-(((R)-tert-butylsulfinyl)amino)-3-(2-fluoro-5-nitrophenyl)butanoate

Guidance literature:: acetic acid methyl ester; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexanes; at -78 ℃;

With triisopropoxytitanium(IV) chloride; In tetrahydrofuran; hexanes; at -78 ℃;

(R)-2-methylpropane-2-sulfinic acid [1-(2-fluoro-5-nitrophenyl)-(E)-ethylidene]amide; In tetrahydrofuran; n-heptane; at -78 ℃;

Reference yield: 75.0%

: 79-20-9
acetic acid methyl ester

: 1076160-56-9
(R)-N-(1-(2-fluoro-5-nitrophenyl)ethylidene)-2-methylpropane-2-sulfinamide

: 1254199-42-2
methyl (S)-3-(((R)-tert-butylsulfinyl)amino)-3-(2-fluoro-5-nitrophenyl)butanoate

Guidance literature:: acetic acid methyl ester; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 1.5h;

With triisopropoxytitanium(IV) chloride; In tetrahydrofuran; hexane; at -78 ℃; for 2h;

(R)-N-(1-(2-fluoro-5-nitrophenyl)ethylidene)-2-methylpropane-2-sulfinamide; In tetrahydrofuran; hexane; at -78 ℃; for 3h;
DOI:10.1021/acs.jmedchem.6b00307

Reference yield:

: 79110-05-7
1-(2-fluoro-5-nitrophenyl)ethanone

: 1254199-42-2
methyl (S)-3-(((R)-tert-butylsulfinyl)amino)-3-(2-fluoro-5-nitrophenyl)butanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: titanium(IV) tetraethanolate / tetrahydrofuran / 5 h / Reflux

2.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 °C

2.2: 0.5 h / -78 °C

With titanium(IV) tetraethanolate; n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane;