Tert-butyloxycarbonyltyrosyl-glycyl-glycyl-phenylalanyl-leucyl-methionine Methyl Ester

Base Information

Chemical Name:Tert-butyloxycarbonyltyrosyl-glycyl-glycyl-phenylalanyl-leucyl-methionine Methyl Ester
CAS No.:98317-56-7
Molecular Formula:C₃₉H₅₆N₆O₁₀S
Molecular Weight:800.974
Hs Code.:

Synonyms:Tert-butyloxycarbonyltyrosyl-glycyl-glycyl-phenylalanyl-leucyl-methionine Methyl Ester

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Chemical Property of Tert-butyloxycarbonyltyrosyl-glycyl-glycyl-phenylalanyl-leucyl-methionine Methyl Ester

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Technology Process of Tert-butyloxycarbonyltyrosyl-glycyl-glycyl-phenylalanyl-leucyl-methionine Methyl Ester

There total 5 articles about Tert-butyloxycarbonyltyrosyl-glycyl-glycyl-phenylalanyl-leucyl-methionine Methyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 10332-17-9,874219-77-9
Met-OMe

: 64963-27-5
N-tert-butyloxycarbonyl-L-tyrosyl-glycyl-glycyl-L-phenylalanyl-L-leucine

: 98317-56-7
Tert-butyloxycarbonyltyrosyl-glycyl-glycyl-phenylalanyl-leucyl-methionine Methyl Ester

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at -20 - 0 ℃; for 1h; 0 deg C, overnight;
DOI:10.1135/cccc19851329

Reference yield:

: 3978-80-1
Boc-Tyr-OH

: 98317-56-7
Tert-butyloxycarbonyltyrosyl-glycyl-glycyl-phenylalanyl-leucyl-methionine Methyl Ester

Guidance literature:: Multi-step reaction with 5 steps

1: 72 percent / 1-hydroxybenzotriazol, dicyclohexylcarbodiimide / dimethylformamide / 1 h / 0 °C

2: hydrogen / palladium black / 2-methyl-propan-2-ol / 8 h

3: dicyclohexylcarbodiimide / CHCl₃ / 3 h / -20 - 0 °C / r.t., overnight

4: 86 percent / hydrogen / palladium black / 2-methyl-propan-2-ol / 16 h

5: 76 percent / 1-hydroxybenzotriazol, dicyclohexylcarbodiimide / dimethylformamide / 1 h / -20 - 0 °C / 0 deg C, overnight

With hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium; In chloroform; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1135/cccc19851329

Reference yield:

: 59481-76-4
tert-butoxycarbonyl-L-tyrosyl-glycyl-glycine

: 98317-56-7
Tert-butyloxycarbonyltyrosyl-glycyl-glycyl-phenylalanyl-leucyl-methionine Methyl Ester

Guidance literature:: Multi-step reaction with 3 steps

1: dicyclohexylcarbodiimide / CHCl₃ / 3 h / -20 - 0 °C / r.t., overnight

2: 86 percent / hydrogen / palladium black / 2-methyl-propan-2-ol / 16 h

3: 76 percent / 1-hydroxybenzotriazol, dicyclohexylcarbodiimide / dimethylformamide / 1 h / -20 - 0 °C / 0 deg C, overnight

With hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium; In chloroform; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1135/cccc19851329