64963-27-5

Upstream product

• 59481-76-4 tert-butoxycarbonyl-L-tyrosyl-glycyl-glycine 
• 77511-32-1 5>-enkephalin 
• 99532-43-1 BOC-Phe-POBT 
• 93957-20-1 Boc-L-Leu-OBt 
• 127485-56-7 Boc-Tyr-OBT 
• 67084-40-6 1-(N-tert-butoxycarbonyl-glycyloxy)-1H-benzotriazole 
• 63631-32-3 (S)-methyl 12-benzyl-2,2-dimethyl-4,7,10-trioxo-3-oxa-5,8,11-triazatridecan-13-oate 
• 61131-30-4 Boc-L-Tyr(Bzl)-Gly-Gly-L-Phe-OH 
• 61196-05-2 Boc-Tyr(Bzl)-Gly-Gly-Phe-OMe 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 61131-29-1 N-glycyl>-L-3-phenylalanine methyl ester hydrochloride 
• 3978-80-1 Boc-Tyr-OH 
• 74193-68-3 N-tert-butyloxycarbonyl-L-phenylalanyl-L-leucine benzyl ester 
• 73994-87-3 (S)-benzyl 2-((S)-2-amino-3-phenylpropanamido)-4-methylpentanoate hydrochloride 

Downstream Products

• 98317-56-7 Tert-butyloxycarbonyltyrosyl-glycyl-glycyl-phenylalanyl-leucyl-methionine Methyl Ester 
• 98317-55-6 Tert-butyloxycarbonyltyrosyl-glycyl-glycyl-phenylalanyl-leucyl-ε-benzyloxycarbonyllysine Benzyl Ester 
• 97640-06-7 tert-butyloxycarbonyltyrosyl-glycyl-glycyl-phenylalanyl-leucyl-N^ε-tert-butyloxycarbonyllysyl-N^ε-tert-butyloxycarbonyllysyl-leucine tert-butyl ester 
• 58822-25-6 Leu-enkephalin 
• 948314-83-8 Leu⁵-Eukephalin 
• 98317-57-8 Tert-butyloxycarbonylmethionyl-tyrosyl-glycyl-glycyl-phenylalanyl-leucine 
• 98317-58-9 (S)-6-Amino-2-{(S)-2-[(S)-2-(2-{2-[(S)-2-tert-butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoylamino}-hexanoic acid 
• 98317-53-4 Tyrosyl-glycyl-glycyl-phenylalanyl-leucyl-methionine 
• 83404-43-7 Tyrosyl-glycyl-glycyl-phenylalanyl-leucyl-lysine 
• 98317-54-5 Methionyl-tyrosyl-glycyl-glycyl-phenylalanyl-leucine 
• 63986-20-9 HCl·H-Tyr(OH)-Gly-Gly-Phe-Leu-OH 

Relevant academic research and scientific papers

Amino acids and peptides. XIX. Preparation of enkephalin-poly(ethylene glycol) hybrid and evaluation of its analgesic activity

The poly(ethylene glycol) hybrid of Leu-enkephalin (Tyr-Gly-Gly-Phe-Leu) was prepared and its analgesic activity was examined. Poly(ethylene glycol) 4000 was converted to amino-poly(ethylene glycol) and coupled with the N(α)- protected pentapeptide, follo

Environmentally benign peptide synthesis using liquid-assisted ball-milling: Application to the synthesis of Leu-enkephalin

This paper describes an original methodology for peptide bond synthesis avoiding toxic solvents and reactants. Ball-milling stoichiometric amounts of Boc-protected α-amino acid N-carboxyanhydrides (Boc-AA-NCA) or Boc-protected α-amino acid N-hydroxysuccin

Solid-phase peptide synthesis in water using microwave-assisted heating

An approach using water as a solvent (coupling and deprotection) was developed for the solid-phase synthesis of peptides using the most common Boc-amlno acid derivatives. Key aspects of this methodology are the use of a PEG-based resin, EDC-HONB as a coupling method, and microwave Irradiation as an energy source.

Glycosylated steroid derivatives for transport across biological membranes and process for making and using same

Novel glycosylated steroid derivatives for facilitating the transport of compounds across biological membranes, either in admixture or as conjugates, are disclosed. A novel process for efficient synthesis of these glycosylated steroid derivatives, using activated glycosyl sulfoxide intermediates is provided. Methods for the permeabilization of membranes and the enhancement of the activity of predetermined compounds are also provided.

Acetol: A useful new protecting group for peptide synthesis

Acetol can be conveniently used as a reagent for the protection of carboxylic acids in peptide synthesis. It has been found to be inert and stable to hydrogenolytic and acidolytic conditions normally used in peptide synthesis. Deblocking has been selectively achieved under mild conditions using Bu4NF .3H2O in THF.

Facile Synthesis of N-Protected Peptide Fragments using Polymer-Bound 1-Hydroxybenzotriazole as an Active Ester

Using polystyrene-bound 1-hydroxybenzotriazole as an active ester and an amino acid or peptide, temporarily C-terminal-protected by a phase-transfer reagent, as a nucleophile, C-terminal-free peptide fragments can be synthesized with very high yield and p

Synthesis of 3H2-Tyr1>Leucine-enkephalin

The synthesis of 3H2-Tyr1>leucine-enkephalin by the catalytic tritiation of 1>leucine-enkephalin is described.The precursor amino acid, 2,6-dibromo-DL-tyrosine, was synthesized in three step

N-Hydroxy Amides. III. Active Esters of Polystyrene-bound 1-Hydroxy-2-pyrrolidinone and Their Use in Peptide Synthesis

A polymer-bond cyclic N-hydroxy amide has been prepared by reaction of aminomethylated copoly(styrene-2percent divinylbenzene) with 1-hydroxy-5-oxo-3-pyrrolidinecarboxylic acid using dicyclohexylcarbodiimide (DCC) as a condensing agent.Several N-blocked α-amino acids have been loaded on this resin by use of DCC.The amino acid resin can be utilized for peptide synthesis.Repetitive usage of the resin in the form of esters and facile synthesis of a biologically active pentapeptide, Leu5-enkephalin, show the usefulness of the polymer-bound 1-hydroxy-2-pyrrolidinone.