3-methyl-4-[2-[N-isobutyl-N-(5-methyl-2-furylsulfonyl)amino]-4,5-5-dimethylphenoxymethyl]benzoic acid methyl ester

Base Information

Chemical Name:3-methyl-4-[2-[N-isobutyl-N-(5-methyl-2-furylsulfonyl)amino]-4,5-5-dimethylphenoxymethyl]benzoic acid methyl ester
CAS No.:459841-25-9
Molecular Formula:C₂₇H₃₃NO₆S
Molecular Weight:499.628
Hs Code.:

Synonyms:3-methyl-4-[2-[N-isobutyl-N-(5-methyl-2-furylsulfonyl)amino]-4,5-5-dimethylphenoxymethyl]benzoic acid methyl ester

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Chemical Property of 3-methyl-4-[2-[N-isobutyl-N-(5-methyl-2-furylsulfonyl)amino]-4,5-5-dimethylphenoxymethyl]benzoic acid methyl ester

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Technology Process of 3-methyl-4-[2-[N-isobutyl-N-(5-methyl-2-furylsulfonyl)amino]-4,5-5-dimethylphenoxymethyl]benzoic acid methyl ester

There total 9 articles about 3-methyl-4-[2-[N-isobutyl-N-(5-methyl-2-furylsulfonyl)amino]-4,5-5-dimethylphenoxymethyl]benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 459841-24-8
3-methyl-4-[2-[N-(5-methyl-2-furylsulfonyl)amino]-4,5-5-dimethylphenoxymethyl]benzoic acid methyl ester

: 513-38-2
Isobutyl iodide

: 459841-25-9
3-methyl-4-[2-[N-isobutyl-N-(5-methyl-2-furylsulfonyl)amino]-4,5-5-dimethylphenoxymethyl]benzoic acid methyl ester

Guidance literature:: With caesium carbonate; dimethyl amine; at 80 ℃;
DOI:10.1016/j.bmc.2006.08.001

Reference yield:

: 68837-59-2
4-bromo-2-methylbenzoic acid

: 459841-25-9
3-methyl-4-[2-[N-isobutyl-N-(5-methyl-2-furylsulfonyl)amino]-4,5-5-dimethylphenoxymethyl]benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 47 percent / lithium aluminum hydride / tetrahydrofuran / 0.17 h / 20 °C

2: 61 percent / triethylamine; dppf / Pd(OAc)2 / dimethylsulfoxide / 2 h / 70 °C

3: 95 percent / PBr₃ / various solvent(s) / 0.5 h / -6 °C

4: 95 percent / potassium carbonate / dimethylformamide / 4 h / 50 °C

5: 100 percent / acetic acid; iron / H₂O / 1 h

6: 100 percent / pyridine / CH₂Cl₂ / 1 h / 20 °C

7: 95 percent / dimethylamine; Cs₂CO₃ / 80 °C

With pyridine; 1,1'-bis-(diphenylphosphino)ferrocene; lithium aluminium tetrahydride; phosphorus tribromide; iron; potassium carbonate; caesium carbonate; acetic acid; dimethyl amine; triethylamine; palladium diacetate; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.08.001

Reference yield:

: 17100-58-2
4-bromo-2-methylbenzyl alcohol

: 459841-25-9
3-methyl-4-[2-[N-isobutyl-N-(5-methyl-2-furylsulfonyl)amino]-4,5-5-dimethylphenoxymethyl]benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 61 percent / triethylamine; dppf / Pd(OAc)2 / dimethylsulfoxide / 2 h / 70 °C

2: 95 percent / PBr₃ / various solvent(s) / 0.5 h / -6 °C

3: 95 percent / potassium carbonate / dimethylformamide / 4 h / 50 °C

4: 100 percent / acetic acid; iron / H₂O / 1 h

5: 100 percent / pyridine / CH₂Cl₂ / 1 h / 20 °C

6: 95 percent / dimethylamine; Cs₂CO₃ / 80 °C

With pyridine; 1,1'-bis-(diphenylphosphino)ferrocene; phosphorus tribromide; iron; potassium carbonate; caesium carbonate; acetic acid; dimethyl amine; triethylamine; palladium diacetate; In dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.08.001