N-cyclopropyl-N-(2-(2-(4-(4-cyclopropylpiperazin-1-yl)-4-((1-oxoisoindolin-2-yl)methyl)piperidin-1-yl)-2-oxoethoxy)ethyl)-4-methoxy-2,6-dimethylbenzenesulfonamide

Base Information

Chemical Name:N-cyclopropyl-N-(2-(2-(4-(4-cyclopropylpiperazin-1-yl)-4-((1-oxoisoindolin-2-yl)methyl)piperidin-1-yl)-2-oxoethoxy)ethyl)-4-methoxy-2,6-dimethylbenzenesulfonamide
CAS No.:1186240-80-1
Molecular Formula:C₃₇H₅₁N₅O₆S
Molecular Weight:693.908
Hs Code.:

N-cyclopropyl-N-(2-(2-(4-(4-cyclopropylpiperazin-1-yl)-4-((1-oxoisoindolin-2-yl)methyl)piperidin-1-yl)-2-oxoethoxy)ethyl)-4-methoxy-2,6-dimethylbenzenesulfonamide

Synonyms:N-cyclopropyl-N-(2-(2-(4-(4-cyclopropylpiperazin-1-yl)-4-((1-oxoisoindolin-2-yl)methyl)piperidin-1-yl)-2-oxoethoxy)ethyl)-4-methoxy-2,6-dimethylbenzenesulfonamide

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Chemical Property of N-cyclopropyl-N-(2-(2-(4-(4-cyclopropylpiperazin-1-yl)-4-((1-oxoisoindolin-2-yl)methyl)piperidin-1-yl)-2-oxoethoxy)ethyl)-4-methoxy-2,6-dimethylbenzenesulfonamide

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Technology Process of N-cyclopropyl-N-(2-(2-(4-(4-cyclopropylpiperazin-1-yl)-4-((1-oxoisoindolin-2-yl)methyl)piperidin-1-yl)-2-oxoethoxy)ethyl)-4-methoxy-2,6-dimethylbenzenesulfonamide

There total 11 articles about N-cyclopropyl-N-(2-(2-(4-(4-cyclopropylpiperazin-1-yl)-4-((1-oxoisoindolin-2-yl)methyl)piperidin-1-yl)-2-oxoethoxy)ethyl)-4-methoxy-2,6-dimethylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 2-[2-[cyclopropyl-[(4-methoxy-2,6-dimethyl-phenyl)sulfonyl]-amino]-ethoxy]-acetic acid

: 1186241-45-1
2-((4-(4-cyclopropylpiperazin-1-yl)piperidin-4-yl)methyl)isoindolin-1-one

: 1186240-80-1
N-cyclopropyl-N-(2-(2-(4-(4-cyclopropylpiperazin-1-yl)-4-((1-oxoisoindolin-2-yl)methyl)piperidin-1-yl)-2-oxoethoxy)ethyl)-4-methoxy-2,6-dimethylbenzenesulfonamide

Guidance literature:: 2-[2-[cyclopropyl-[(4-methoxy-2,6-dimethyl-phenyl)sulfonyl]-amino]-ethoxy]-acetic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 25 ℃; for 0.25h;

2-((4-(4-cyclopropylpiperazin-1-yl)piperidin-4-yl)methyl)isoindolin-1-one; In dichloromethane; at 0 - 25 ℃; for 16h;

Reference yield:

: 775287-75-7
N-cyclopropyl-N-(2-hydroxyethyl)-4-methoxy-2,6-dimethylbenzene-sulphonamide

: 1186240-80-1
N-cyclopropyl-N-(2-(2-(4-(4-cyclopropylpiperazin-1-yl)-4-((1-oxoisoindolin-2-yl)methyl)piperidin-1-yl)-2-oxoethoxy)ethyl)-4-methoxy-2,6-dimethylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / tetrabutyl-ammonium chloride / water; toluene / 0 - 25 °C

2.1: trifluoroacetic acid / dichloromethane / 2 h / 0 - 25 °C

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 0 - 25 °C

3.2: 16 h / 0 - 25 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; tetrabutyl-ammonium chloride; In dichloromethane; water; toluene;

Reference yield:

: 55661-08-0
4-methoxy-2,6-dimethylbenzenesulfonyl chloride

: 1186240-80-1
N-cyclopropyl-N-(2-(2-(4-(4-cyclopropylpiperazin-1-yl)-4-((1-oxoisoindolin-2-yl)methyl)piperidin-1-yl)-2-oxoethoxy)ethyl)-4-methoxy-2,6-dimethylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 0 - 25 °C

2.1: sodium hydroxide / tetrabutyl-ammonium chloride / water; toluene / 0 - 25 °C

3.1: trifluoroacetic acid / dichloromethane / 2 h / 0 - 25 °C

4.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 0 - 25 °C

4.2: 16 h / 0 - 25 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; tetrabutyl-ammonium chloride; In dichloromethane; water; toluene;