4-methyl-N-[5-methoxyl-2-(pyridin-2-yl)phenyl]benzenesulfonamide

Base Information

• Chemical Name: 4-methyl-N-[5-methoxyl-2-(pyridin-2-yl)phenyl]benzenesulfonamide
• CAS No.: 1379667-13-6
• Molecular Formula: C₁₉H₁₈N₂O₃S
• Molecular Weight: 354.43
• Mol file: 1379667-13-6.mol

Synonyms:4-methyl-N-[5-methoxyl-2-(pyridin-2-yl)phenyl]benzenesulfonamide

Chemical Property of 4-methyl-N-[5-methoxyl-2-(pyridin-2-yl)phenyl]benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-methyl-N-[5-methoxyl-2-(pyridin-2-yl)phenyl]benzenesulfonamide

There total 5 articles about 4-methyl-N-[5-methoxyl-2-(pyridin-2-yl)phenyl]benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-(2-pyridinyl)anisole (5957-90-4) + Zhdankin’s reagent → 4-methyl-N-[5-methoxyl-2-(pyridin-2-yl)phenyl]benzenesulfonamide (1379667-13-6)

Guidance literature:

With silver hexafluoroantimonate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; potassium acetate; In 1,2-dichloro-ethane; at 80 ℃; for 15h; regioselective reaction;

DOI:10.1021/acscatal.6b02015

Reference yield: 89.0%

4-toluenesulfonyl azide (941-55-9) + 4-(2-pyridinyl)anisole (5957-90-4) → 4-methyl-N-[5-methoxyl-2-(pyridin-2-yl)phenyl]benzenesulfonamide (1379667-13-6)

Guidance literature:

With bromopentacarbonylmanganese(I); tetrabutylammomium bromide; In water; at 120 ℃; for 16h; regioselective reaction;

DOI:10.1002/adsc.201800544

Reference yield: 74.0%

4-(2-pyridinyl)anisole (5957-90-4) + toluene-4-sulfonamide (70-55-3) → 4-methyl-N-[5-methoxyl-2-(pyridin-2-yl)phenyl]benzenesulfonamide (1379667-13-6)

Guidance literature:

With silver hexafluoroantimonate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; [bis(acetoxy)iodo]benzene; In dichloromethane; at 60 ℃; for 24h; Schlenk technique; Inert atmosphere;

DOI:10.1021/ol4024776

upstream raw materials:

2-bromo-pyridine

4-methoxyphenylboronic acid

4-toluenesulfonyl azide

4-(2-pyridinyl)anisole