Technology Process of 4,4'-difluoro-2,3,5-triphenyl-8-trifluoromethyl-4-bora-3a,4a-diaza-sindacene
There total 6 articles about 4,4'-difluoro-2,3,5-triphenyl-8-trifluoromethyl-4-bora-3a,4a-diaza-sindacene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2,3-diphenyl-5-[2,2,2-trifluoro-1-(5-phenylpyrrol-2-yl)ethyl]pyrrole;
With
2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
dichloromethane;
at 20 ℃;
for 1h;
With
N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at 20 ℃;
for 0.166667h;
With
boron trifluoride diethyl etherate;
In
dichloromethane;
at 20 ℃;
for 1h;
DOI:10.1021/ol200360f
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: pyridine / diethyl ether / 2.5 h
2.1: sodium tetrahydroborate; sodium hydrogencarbonate / methanol / 0.67 h
3.1: phosphorus pentoxide / dichloromethane / 20 °C / Inert atmosphere
4.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 1 h / 20 °C
4.2: 0.17 h / 20 °C
4.3: 1 h / 20 °C
With
pyridine; sodium tetrahydroborate; phosphorus pentoxide; sodium hydrogencarbonate; 2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
methanol; diethyl ether; dichloromethane;
DOI:10.1021/ol200360f
- Guidance literature:
-
Multi-step reaction with 5 steps
2.1: pyridine / diethyl ether / 2.5 h
3.1: sodium tetrahydroborate; sodium hydrogencarbonate / methanol / 0.67 h
4.1: phosphorus pentoxide / dichloromethane / 20 °C / Inert atmosphere
5.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 1 h / 20 °C
5.2: 0.17 h / 20 °C
5.3: 1 h / 20 °C
With
pyridine; sodium tetrahydroborate; phosphorus pentoxide; sodium hydrogencarbonate; 2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
methanol; diethyl ether; dichloromethane;
1.1: Trofimov reaction;
DOI:10.1021/ol200360f
![2,3-diphenyl-5-[2,2,2-trifluoro-1-(5-phenylpyrrol-2-yl)ethyl]pyrrole](/Databaselist/images/loading.webp)
