5-(2-(3,5-dibromo-4-methoxyphenyl)acetamido)-N,N,N-trimethylpentan-1-aminium iodide

Base Information

• Chemical Name: 5-(2-(3,5-dibromo-4-methoxyphenyl)acetamido)-N,N,N-trimethylpentan-1-aminium iodide
• CAS No.: 1563242-93-2
• Molecular Formula: C₁₇H₂₇Br₂N₂O₂*I
• Molecular Weight: 578.126
• Mol file: 1563242-93-2.mol

Synonyms:5-(2-(3,5-dibromo-4-methoxyphenyl)acetamido)-N,N,N-trimethylpentan-1-aminium iodide

Chemical Property of 5-(2-(3,5-dibromo-4-methoxyphenyl)acetamido)-N,N,N-trimethylpentan-1-aminium iodide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(2-(3,5-dibromo-4-methoxyphenyl)acetamido)-N,N,N-trimethylpentan-1-aminium iodide

There total 4 articles about 5-(2-(3,5-dibromo-4-methoxyphenyl)acetamido)-N,N,N-trimethylpentan-1-aminium iodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-(3,5-dibromo-4-methoxyphenyl)-N-(5-(dimethylamino)pentyl)acetamide (1563242-87-4) + methyl iodide (74-88-4) → 5-(2-(3,5-dibromo-4-methoxyphenyl)acetamido)-N,N,N-trimethylpentan-1-aminium iodide (1563242-93-2)

Guidance literature:

In acetone; at 20 ℃; for 1h;

Reference yield:

4-Methoxyphenylacetic acid (104-01-8) → 5-(2-(3,5-dibromo-4-methoxyphenyl)acetamido)-N,N,N-trimethylpentan-1-aminium iodide (1563242-93-2)

Guidance literature:

Multi-step reaction with 5 steps

1: thionyl chloride / 4 h / 70 °C

2: iron(III) chloride; N-Bromosuccinimide / Trichloroethylene; acetonitrile / 5 h / 20 °C

3: water; sodium hydroxide / tetrahydrofuran / 6 h / 20 °C

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / dichloromethane / 6 h / 20 °C / Inert atmosphere

5: acetone / 1 h / 20 °C

With iron(III) chloride; N-Bromosuccinimide; thionyl chloride; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; dichloromethane; Trichloroethylene; acetone; acetonitrile;

Reference yield:

4-methoxy-phenyl acetic acid methyl ester (23786-14-3) → 5-(2-(3,5-dibromo-4-methoxyphenyl)acetamido)-N,N,N-trimethylpentan-1-aminium iodide (1563242-93-2)

Guidance literature:

Multi-step reaction with 4 steps

1: iron(III) chloride; N-Bromosuccinimide / Trichloroethylene; acetonitrile / 5 h / 20 °C

2: water; sodium hydroxide / tetrahydrofuran / 6 h / 20 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / dichloromethane / 6 h / 20 °C / Inert atmosphere

4: acetone / 1 h / 20 °C

With iron(III) chloride; N-Bromosuccinimide; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; dichloromethane; Trichloroethylene; acetone; acetonitrile;

upstream raw materials:

2-(3,5-dibromo-4-methoxyphenyl)-N-(5-(dimethylamino)pentyl)acetamide

methyl iodide

4-Methoxyphenylacetic acid

4-methoxy-phenyl acetic acid methyl ester

Refernces

• 1、 Tadesse, Margey,Svenson, Johan,Sepcic, Kristina,Trembleau, Laurent,Engqvist, Magnus,Andersen, Jeanette H.,Jaspars, Marcel,Stensvaisg, Klara,Haug, Tor. "Isolation and synthesis of pulmonarins A and B, acetylcholinesterase inhibitors from the colonial ascidian Synoicum pulmonaria". . p. 364 - 369. Retrieved 2014/03/21.