6-(tert-butyldiphenylsilyloxy)-3(S),5(S)-dimethyl-2(S)-(methoxymethoxy)hexan-1-ol

Base Information

Chemical Name:6-(tert-butyldiphenylsilyloxy)-3(S),5(S)-dimethyl-2(S)-(methoxymethoxy)hexan-1-ol
CAS No.:910043-08-2
Molecular Formula:C₂₆H₄₀O₄Si
Molecular Weight:444.687
Hs Code.:

Synonyms:6-(tert-butyldiphenylsilyloxy)-3(S),5(S)-dimethyl-2(S)-(methoxymethoxy)hexan-1-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-(tert-butyldiphenylsilyloxy)-3(S),5(S)-dimethyl-2(S)-(methoxymethoxy)hexan-1-ol

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Technology Process of 6-(tert-butyldiphenylsilyloxy)-3(S),5(S)-dimethyl-2(S)-(methoxymethoxy)hexan-1-ol

There total 6 articles about 6-(tert-butyldiphenylsilyloxy)-3(S),5(S)-dimethyl-2(S)-(methoxymethoxy)hexan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 136786-39-5
benzyl [6-(tert-butyldiphenylsilyloxy)-3(S),5(S)-dimethyl-2(S)-(methoxymethoxy)hex-1-yl] ether

: 910043-08-2
6-(tert-butyldiphenylsilyloxy)-3(S),5(S)-dimethyl-2(S)-(methoxymethoxy)hexan-1-ol

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; at 25 ℃; for 10h; under 760 Torr;
DOI:10.1016/S0040-4039(00)79871-6

Reference yield:

: 136786-36-2
(2S,3S,5S)-1-(benzyloxy)-6-(tert-butyldiphenylsilyloxy)-3,5-dimethylhexan-2-ol

: 910043-08-2
6-(tert-butyldiphenylsilyloxy)-3(S),5(S)-dimethyl-2(S)-(methoxymethoxy)hexan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / iPr₂NEt; TBAI / CH₂Cl₂ / 48 h / 20 °C

2: 86 percent / hydrogen / Pd/C / ethanol / 760 Torr

With hydrogen; tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1021/ja0581346

Reference yield:

: 910043-29-7
(2S,4E)-6-[(4-methoxyphenyl)methoxy]-2-methylhex-4-en-1-ol

: 910043-08-2
6-(tert-butyldiphenylsilyloxy)-3(S),5(S)-dimethyl-2(S)-(methoxymethoxy)hexan-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: imidazole / dimethylformamide / 15 h / 20 °C

1.2: DDQ; water / CH₂Cl₂ / 0.25 h / 20 °C

1.3: 72 percent / NaBH₄ / CH₂Cl₂ / 24 h / 20 °C

2.1: (-)-DET; tBuOOH; 4A MS / Ti(OiPr)4 / CH₂Cl₂ / 24 h / -40 - -23 °C

2.2: 2.42 g / KH; TBAI / tetrahydrofuran / 0.75 h / 0 - 20 °C

3.1: 78 percent / nBuLi / petroleum ether / 3 h / -30 - 0 °C

4.1: 89 percent / iPr₂NEt; TBAI / CH₂Cl₂ / 48 h / 20 °C

5.1: 86 percent / hydrogen / Pd/C / ethanol / 760 Torr

With 1H-imidazole; tert.-butylhydroperoxide; n-butyllithium; hydrogen; tetra-(n-butyl)ammonium iodide; (-)-diethyl tartrate; N-ethyl-N,N-diisopropylamine; titanium(IV) isopropylate; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide; Petroleum ether;
DOI:10.1021/ja0581346