9H-fluoren-9-ylmethyl [(2S)-1-({2-[(tert-butoxycarbonyl)amino]ethyl} amino)-1-oxo-3-phenylpropan-2-yl]carbamate

Base Information

• Chemical Name: 9H-fluoren-9-ylmethyl [(2S)-1-({2-[(tert-butoxycarbonyl)amino]ethyl} amino)-1-oxo-3-phenylpropan-2-yl]carbamate
• CAS No.: 528584-52-3
• Molecular Formula: C₃₁H₃₅N₃O₅
• Molecular Weight: 529.636
• Mol file: 528584-52-3.mol

Synonyms:9H-fluoren-9-ylmethyl [(2S)-1-({2-[(tert-butoxycarbonyl)amino]ethyl} amino)-1-oxo-3-phenylpropan-2-yl]carbamate

Chemical Property of 9H-fluoren-9-ylmethyl [(2S)-1-({2-[(tert-butoxycarbonyl)amino]ethyl} amino)-1-oxo-3-phenylpropan-2-yl]carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 9H-fluoren-9-ylmethyl [(2S)-1-({2-[(tert-butoxycarbonyl)amino]ethyl} amino)-1-oxo-3-phenylpropan-2-yl]carbamate

There total 4 articles about 9H-fluoren-9-ylmethyl [(2S)-1-({2-[(tert-butoxycarbonyl)amino]ethyl} amino)-1-oxo-3-phenylpropan-2-yl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

→ 9H-fluoren-9-ylmethyl [(2S)-1-({2-[(tert-butoxycarbonyl)amino]ethyl} amino)-1-oxo-3-phenylpropan-2-yl]carbamate (528584-52-3)

Guidance literature:

With triethylamine; HATU; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

N-BOC-1,2-diaminoethane (57260-73-8) + N-Fmoc L-Phe (35661-40-6) + N-ethyl-N,N-diisopropylamine (7087-68-5) → 9H-fluoren-9-ylmethyl [(2S)-1-({2-[(tert-butoxycarbonyl)amino]ethyl} amino)-1-oxo-3-phenylpropan-2-yl]carbamate (528584-52-3)

Guidance literature:

With N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

N-BOC-1,2-diaminoethane (57260-73-8) + N-Fmoc L-Phe (35661-40-6) → 9H-fluoren-9-ylmethyl [(2S)-1-({2-[(tert-butoxycarbonyl)amino]ethyl} amino)-1-oxo-3-phenylpropan-2-yl]carbamate (528584-52-3)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 1h;

DOI:10.1080/14756366.2017.1334649

upstream raw materials:

N-BOC-1,2-diaminoethane

N-Fmoc L-Phe

N-ethyl-N,N-diisopropylamine

di-tert-butyl dicarbonate

Downstream raw materials:

N-[2-(tert-butoxycarbonylamino)ethyl]-2-(S)-amino-3-phenylpropionamide