Technology Process of (R)-1-ethyl-3-(3-fluorobenzyl)pyrrolidine
There total 5 articles about (R)-1-ethyl-3-(3-fluorobenzyl)pyrrolidine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium carbonate;
In
acetonitrile;
at 20 ℃;
for 2.5h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 1H-imidazole; triphenylphosphine; iodine / 1,4-dioxane; diethyl ether / 20 °C / Cooling with ice
1.2: 20 °C
2.1: (1R,2R)-trans-2-aminocyclohexanol hydrochloride; sodium hexamethyldisilazane / nickel(I) iodide / isopropyl alcohol / 0.08 h / 40 °C / Sealed tube; Inert atmosphere
2.2: 70 °C
3.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
4.1: potassium carbonate / acetonitrile / 2.5 h / 20 °C
With
1H-imidazole; iodine; sodium hexamethyldisilazane; potassium carbonate; triphenylphosphine; (1R,2R)-trans-2-aminocyclohexanol hydrochloride; trifluoroacetic acid;
nickel(I) iodide;
In
1,4-dioxane; diethyl ether; dichloromethane; isopropyl alcohol; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: (1R,2R)-trans-2-aminocyclohexanol hydrochloride; sodium hexamethyldisilazane / nickel(I) iodide / isopropyl alcohol / 0.08 h / 40 °C / Sealed tube; Inert atmosphere
1.2: 70 °C
2.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
3.1: potassium carbonate / acetonitrile / 2.5 h / 20 °C
With
sodium hexamethyldisilazane; potassium carbonate; (1R,2R)-trans-2-aminocyclohexanol hydrochloride; trifluoroacetic acid;
nickel(I) iodide;
In
dichloromethane; isopropyl alcohol; acetonitrile;
