2-oxo-2-(6-(4-(2-(piperidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethyl acetate

Base Information

Chemical Name:2-oxo-2-(6-(4-(2-(piperidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethyl acetate
CAS No.:1181691-17-7
Molecular Formula:C₂₆H₃₂N₂O₃
Molecular Weight:420.552
Hs Code.:

Synonyms:2-oxo-2-(6-(4-(2-(piperidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethyl acetate

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Chemical Property of 2-oxo-2-(6-(4-(2-(piperidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethyl acetate

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Technology Process of 2-oxo-2-(6-(4-(2-(piperidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethyl acetate

There total 8 articles about 2-oxo-2-(6-(4-(2-(piperidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-89-4
piperidine

: 1181691-16-6
2-oxo-2-(6-(4-(2-(tosyloxy)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethyl acetate

: 1181691-17-7
2-oxo-2-(6-(4-(2-(piperidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethyl acetate

Guidance literature:: With sodium carbonate; In acetonitrile; at 100 ℃; for 3h; Microwave irradiation;

Reference yield:

: 215798-19-9
6-bromo-1,2,3,4-tetrahydroisoquinolinehydrochloride

: 1181691-17-7
2-oxo-2-(6-(4-(2-(piperidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethyl acetate

Guidance literature:: Multi-step reaction with 8 steps

1: (R)-2-hydroxy-1-(6-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone hydrochloride / dichloromethane / 0.5 h / 20 °C

2: sodium hydrogencarbonate / ethanol; benzene / 3 h / 100 °C / Inert atmosphere; Microwave irradiation

3: methanol; sodium hydroxide / 0.33 h

4: triethylamine / dichloromethane / 20 °C

5: triethylamine / dichloromethane / 0.5 h / 20 °C

6: water; hydrogen bromide / tetrahydrofuran / 1.5 h / 20 °C

7: triethylamine / dichloromethane / 0.5 h

8: sodium carbonate / acetonitrile / 3 h / 100 °C / Microwave irradiation

With methanol; (R)-2-hydroxy-1-(6-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone hydrochloride; water; hydrogen bromide; sodium hydrogencarbonate; sodium carbonate; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile; benzene; 2: Suzuki Coupling;

Reference yield:

: 1181691-11-1
2-hydroxy-1-(6-(4-(2-hydroxyethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone

: 1181691-17-7
2-oxo-2-(6-(4-(2-(piperidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethyl acetate

Guidance literature:: Multi-step reaction with 6 steps

1: methanol; sodium hydroxide / 0.33 h

2: triethylamine / dichloromethane / 20 °C

3: triethylamine / dichloromethane / 0.5 h / 20 °C

4: water; hydrogen bromide / tetrahydrofuran / 1.5 h / 20 °C

5: triethylamine / dichloromethane / 0.5 h

6: sodium carbonate / acetonitrile / 3 h / 100 °C / Microwave irradiation

With methanol; water; hydrogen bromide; sodium carbonate; triethylamine; sodium hydroxide; In tetrahydrofuran; dichloromethane; acetonitrile;