2-hydroxy-1-(6-(4-(2-hydroxyethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone

Base Information

Chemical Name:2-hydroxy-1-(6-(4-(2-hydroxyethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone
CAS No.:1181691-11-1
Molecular Formula:C₁₉H₂₁NO₃
Molecular Weight:311.381
Hs Code.:

Synonyms:2-hydroxy-1-(6-(4-(2-hydroxyethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone

Suppliers and Price of 2-hydroxy-1-(6-(4-(2-hydroxyethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone

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Chemical Property of 2-hydroxy-1-(6-(4-(2-hydroxyethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone

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Technology Process of 2-hydroxy-1-(6-(4-(2-hydroxyethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone

There total 2 articles about 2-hydroxy-1-(6-(4-(2-hydroxyethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1035099-75-2
(4-{2-[(tert-butyldimethylsilyl)oxy]ethyl}phenyl)boronic acid

: 1181691-10-0
2-(6-bromo-3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl acetate

: 1181691-11-1
2-hydroxy-1-(6-(4-(2-hydroxyethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone

Guidance literature:: With sodium hydrogencarbonate; In ethanol; benzene; at 100 ℃; for 3h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 215798-19-9
6-bromo-1,2,3,4-tetrahydroisoquinolinehydrochloride

: 1181691-11-1
2-hydroxy-1-(6-(4-(2-hydroxyethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: (R)-2-hydroxy-1-(6-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone hydrochloride / dichloromethane / 0.5 h / 20 °C

2: sodium hydrogencarbonate / ethanol; benzene / 3 h / 100 °C / Inert atmosphere; Microwave irradiation

With (R)-2-hydroxy-1-(6-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone hydrochloride; sodium hydrogencarbonate; In ethanol; dichloromethane; benzene; 2: Suzuki Coupling;