2-oxo-2-(6-(4-(2-(tosyloxy)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethyl acetate

Base Information

Chemical Name:2-oxo-2-(6-(4-(2-(tosyloxy)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethyl acetate
CAS No.:1181691-16-6
Molecular Formula:C₂₈H₂₉NO₆S
Molecular Weight:507.607
Hs Code.:

Synonyms:2-oxo-2-(6-(4-(2-(tosyloxy)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethyl acetate

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Chemical Property of 2-oxo-2-(6-(4-(2-(tosyloxy)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethyl acetate

Chemical Property:

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Technology Process of 2-oxo-2-(6-(4-(2-(tosyloxy)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethyl acetate

There total 7 articles about 2-oxo-2-(6-(4-(2-(tosyloxy)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1181691-15-5
2-(6-(4-(2-hydroxyethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl acetate

: 98-59-9
p-toluenesulfonyl chloride

: 1181691-16-6
2-oxo-2-(6-(4-(2-(tosyloxy)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethyl acetate

Guidance literature:: With triethylamine; In dichloromethane; for 0.5h;

Reference yield:

: 215798-19-9
6-bromo-1,2,3,4-tetrahydroisoquinolinehydrochloride

: 1181691-16-6
2-oxo-2-(6-(4-(2-(tosyloxy)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethyl acetate

Guidance literature:: Multi-step reaction with 7 steps

1: (R)-2-hydroxy-1-(6-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone hydrochloride / dichloromethane / 0.5 h / 20 °C

2: sodium hydrogencarbonate / ethanol; benzene / 3 h / 100 °C / Inert atmosphere; Microwave irradiation

3: methanol; sodium hydroxide / 0.33 h

4: triethylamine / dichloromethane / 20 °C

5: triethylamine / dichloromethane / 0.5 h / 20 °C

6: water; hydrogen bromide / tetrahydrofuran / 1.5 h / 20 °C

7: triethylamine / dichloromethane / 0.5 h

With methanol; (R)-2-hydroxy-1-(6-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone hydrochloride; water; hydrogen bromide; sodium hydrogencarbonate; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; benzene; 2: Suzuki Coupling;

Reference yield:

: 1181691-11-1
2-hydroxy-1-(6-(4-(2-hydroxyethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone

: 1181691-16-6
2-oxo-2-(6-(4-(2-(tosyloxy)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethyl acetate

Guidance literature:: Multi-step reaction with 5 steps

1: methanol; sodium hydroxide / 0.33 h

2: triethylamine / dichloromethane / 20 °C

3: triethylamine / dichloromethane / 0.5 h / 20 °C

4: water; hydrogen bromide / tetrahydrofuran / 1.5 h / 20 °C

5: triethylamine / dichloromethane / 0.5 h

With methanol; water; hydrogen bromide; triethylamine; sodium hydroxide; In tetrahydrofuran; dichloromethane;