2-hydroxy-1-(6-(4-(2-(piperidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone trifluoroacetate

Base Information

Chemical Name:2-hydroxy-1-(6-(4-(2-(piperidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone trifluoroacetate
CAS No.:1181692-15-8
Molecular Formula:C₂HF₃O₂*C₂₄H₃₀N₂O₂
Molecular Weight:492.538
Hs Code.:

Synonyms:2-hydroxy-1-(6-(4-(2-(piperidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone trifluoroacetate

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Chemical Property of 2-hydroxy-1-(6-(4-(2-(piperidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone trifluoroacetate

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Technology Process of 2-hydroxy-1-(6-(4-(2-(piperidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone trifluoroacetate

There total 9 articles about 2-hydroxy-1-(6-(4-(2-(piperidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1181691-17-7
2-oxo-2-(6-(4-(2-(piperidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethyl acetate

: 1181692-15-8
2-hydroxy-1-(6-(4-(2-(piperidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone trifluoroacetate

Guidance literature:: With hydrogenchloride; isopropyl alcohol; In 1,4-dioxane; at 20 ℃; for 1h;

Reference yield:

: 215798-19-9
6-bromo-1,2,3,4-tetrahydroisoquinolinehydrochloride

: 1181692-15-8
2-hydroxy-1-(6-(4-(2-(piperidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone trifluoroacetate

Guidance literature:: Multi-step reaction with 9 steps

1: (R)-2-hydroxy-1-(6-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone hydrochloride / dichloromethane / 0.5 h / 20 °C

2: sodium hydrogencarbonate / ethanol; benzene / 3 h / 100 °C / Inert atmosphere; Microwave irradiation

3: methanol; sodium hydroxide / 0.33 h

4: triethylamine / dichloromethane / 20 °C

5: triethylamine / dichloromethane / 0.5 h / 20 °C

6: water; hydrogen bromide / tetrahydrofuran / 1.5 h / 20 °C

7: triethylamine / dichloromethane / 0.5 h

8: sodium carbonate / acetonitrile / 3 h / 100 °C / Microwave irradiation

9: hydrogenchloride; isopropyl alcohol / 1,4-dioxane / 1 h / 20 °C

With hydrogenchloride; methanol; (R)-2-hydroxy-1-(6-(4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone hydrochloride; water; hydrogen bromide; sodium hydrogencarbonate; sodium carbonate; triethylamine; isopropyl alcohol; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; acetonitrile; benzene; 2: Suzuki Coupling;

Reference yield:

: 1181691-15-5
2-(6-(4-(2-hydroxyethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl acetate

: 1181692-15-8
2-hydroxy-1-(6-(4-(2-(piperidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 0.5 h

2: sodium carbonate / acetonitrile / 3 h / 100 °C / Microwave irradiation

3: hydrogenchloride; isopropyl alcohol / 1,4-dioxane / 1 h / 20 °C

With hydrogenchloride; sodium carbonate; triethylamine; isopropyl alcohol; In 1,4-dioxane; dichloromethane; acetonitrile;