1-(3-isopropyl-1,2,4-oxadiazol-5-y)l-4-[(1R,2R)-2-({[4-(methylsulfonyl)benzyl]oxy}methyl)cyclopropyl]piperidine

Base Information

Chemical Name:1-(3-isopropyl-1,2,4-oxadiazol-5-y)l-4-[(1R,2R)-2-({[4-(methylsulfonyl)benzyl]oxy}methyl)cyclopropyl]piperidine
CAS No.:1416364-34-5
Molecular Formula:C₂₂H₃₁N₃O₄S
Molecular Weight:433.572
Hs Code.:

Synonyms:1-(3-isopropyl-1,2,4-oxadiazol-5-y)l-4-[(1R,2R)-2-({[4-(methylsulfonyl)benzyl]oxy}methyl)cyclopropyl]piperidine

Suppliers and Price of 1-(3-isopropyl-1,2,4-oxadiazol-5-y)l-4-[(1R,2R)-2-({[4-(methylsulfonyl)benzyl]oxy}methyl)cyclopropyl]piperidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-(3-isopropyl-1,2,4-oxadiazol-5-y)l-4-[(1R,2R)-2-({[4-(methylsulfonyl)benzyl]oxy}methyl)cyclopropyl]piperidine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-(3-isopropyl-1,2,4-oxadiazol-5-y)l-4-[(1R,2R)-2-({[4-(methylsulfonyl)benzyl]oxy}methyl)cyclopropyl]piperidine

There total 3 articles about 1-(3-isopropyl-1,2,4-oxadiazol-5-y)l-4-[(1R,2R)-2-({[4-(methylsulfonyl)benzyl]oxy}methyl)cyclopropyl]piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 35613-84-4
isobutyramide oxime

: 1416366-18-1
4-[(1R,2R)-2-({[4-(methylsulfonyl)benzyl]oxy}methyl)cyclopropyl]piperidine-carbonitrile

: 1416364-34-5
1-(3-isopropyl-1,2,4-oxadiazol-5-y)l-4-[(1R,2R)-2-({[4-(methylsulfonyl)benzyl]oxy}methyl)cyclopropyl]piperidine

Guidance literature:: isobutyramide oxime; 4-[(1R,2R)-2-({[4-(methylsulfonyl)benzyl]oxy}methyl)cyclopropyl]piperidine-carbonitrile; With zinc(II) chloride; In tetrahydrofuran; diethyl ether; at 20 ℃; for 3h;

With hydrogenchloride; In tetrahydrofuran; 1,4-dioxane; diethyl ether; at 90 ℃; for 1h;

Reference yield:

: 1416366-21-6
4-((1R,2R)-2-{[(4-bromobenzyl)oxy]methyl}cyclopropyl)piperidine trifluoroacetate

: 1416364-34-5
1-(3-isopropyl-1,2,4-oxadiazol-5-y)l-4-[(1R,2R)-2-({[4-(methylsulfonyl)benzyl]oxy}methyl)cyclopropyl]piperidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C

2.1: N,N`-dimethylethylenediamine / copper(I) trifluoromethanesulfonate benzene complex / dimethyl sulfoxide / 120 °C / Inert atmosphere; Sealed vial

3.1: zinc(II) chloride / diethyl ether; tetrahydrofuran / 3 h / 20 °C

3.2: 1 h / 90 °C

With N-ethyl-N,N-diisopropylamine; zinc(II) chloride; N,N`-dimethylethylenediamine; copper(I) trifluoromethanesulfonate benzene complex; In tetrahydrofuran; diethyl ether; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 1416366-22-7
4-((1R,2R)-2-{[(4-bromobenzyl)oxy]methyl}cyclopropyl)piperidine-1-carbonitrile

: 1416364-34-5
1-(3-isopropyl-1,2,4-oxadiazol-5-y)l-4-[(1R,2R)-2-({[4-(methylsulfonyl)benzyl]oxy}methyl)cyclopropyl]piperidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: N,N`-dimethylethylenediamine / copper(I) trifluoromethanesulfonate benzene complex / dimethyl sulfoxide / 120 °C / Inert atmosphere; Sealed vial

2.1: zinc(II) chloride / diethyl ether; tetrahydrofuran / 3 h / 20 °C

2.2: 1 h / 90 °C

With zinc(II) chloride; N,N`-dimethylethylenediamine; copper(I) trifluoromethanesulfonate benzene complex; In tetrahydrofuran; diethyl ether; dimethyl sulfoxide;