4-[(1R,2R)-2-({[4-(methylsulfonyl)benzyl]oxy}methyl)cyclopropyl]piperidine-carbonitrile

Base Information

Chemical Name:4-[(1R,2R)-2-({[4-(methylsulfonyl)benzyl]oxy}methyl)cyclopropyl]piperidine-carbonitrile
CAS No.:1416366-18-1
Molecular Formula:C₁₈H₂₄N₂O₃S
Molecular Weight:348.466
Hs Code.:

Synonyms:4-[(1R,2R)-2-({[4-(methylsulfonyl)benzyl]oxy}methyl)cyclopropyl]piperidine-carbonitrile

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Chemical Property of 4-[(1R,2R)-2-({[4-(methylsulfonyl)benzyl]oxy}methyl)cyclopropyl]piperidine-carbonitrile

Chemical Property:

Purity/Quality:

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Technology Process of 4-[(1R,2R)-2-({[4-(methylsulfonyl)benzyl]oxy}methyl)cyclopropyl]piperidine-carbonitrile

There total 2 articles about 4-[(1R,2R)-2-({[4-(methylsulfonyl)benzyl]oxy}methyl)cyclopropyl]piperidine-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1416366-22-7
4-((1R,2R)-2-{[(4-bromobenzyl)oxy]methyl}cyclopropyl)piperidine-1-carbonitrile

: 20277-69-4
sodium methansulfinate

: 1416366-18-1
4-[(1R,2R)-2-({[4-(methylsulfonyl)benzyl]oxy}methyl)cyclopropyl]piperidine-carbonitrile

Guidance literature:: With N,N`-dimethylethylenediamine; copper(I) trifluoromethanesulfonate benzene complex; In dimethyl sulfoxide; at 120 ℃; Inert atmosphere; Sealed vial;

Reference yield:

: 1416366-21-6
4-((1R,2R)-2-{[(4-bromobenzyl)oxy]methyl}cyclopropyl)piperidine trifluoroacetate

: 1416366-18-1
4-[(1R,2R)-2-({[4-(methylsulfonyl)benzyl]oxy}methyl)cyclopropyl]piperidine-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C

2: N,N`-dimethylethylenediamine / copper(I) trifluoromethanesulfonate benzene complex / dimethyl sulfoxide / 120 °C / Inert atmosphere; Sealed vial

With N-ethyl-N,N-diisopropylamine; N,N`-dimethylethylenediamine; copper(I) trifluoromethanesulfonate benzene complex; In dimethyl sulfoxide; acetonitrile;

Reference yield:

: 35613-84-4
isobutyramide oxime

: 1416366-18-1
4-[(1R,2R)-2-({[4-(methylsulfonyl)benzyl]oxy}methyl)cyclopropyl]piperidine-carbonitrile

: 1416364-34-5
1-(3-isopropyl-1,2,4-oxadiazol-5-y)l-4-[(1R,2R)-2-({[4-(methylsulfonyl)benzyl]oxy}methyl)cyclopropyl]piperidine

Guidance literature:: isobutyramide oxime; 4-[(1R,2R)-2-({[4-(methylsulfonyl)benzyl]oxy}methyl)cyclopropyl]piperidine-carbonitrile; With zinc(II) chloride; In tetrahydrofuran; diethyl ether; at 20 ℃; for 3h;

With hydrogenchloride; In tetrahydrofuran; 1,4-dioxane; diethyl ether; at 90 ℃; for 1h;