4-((1R,2R)-2-{[(4-bromobenzyl)oxy]methyl}cyclopropyl)piperidine-1-carbonitrile

Base Information

Chemical Name:4-((1R,2R)-2-{[(4-bromobenzyl)oxy]methyl}cyclopropyl)piperidine-1-carbonitrile
CAS No.:1416366-22-7
Molecular Formula:C₁₇H₂₁BrN₂O
Molecular Weight:349.271
Hs Code.:

Synonyms:4-((1R,2R)-2-{[(4-bromobenzyl)oxy]methyl}cyclopropyl)piperidine-1-carbonitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-((1R,2R)-2-{[(4-bromobenzyl)oxy]methyl}cyclopropyl)piperidine-1-carbonitrile

Chemical Property:

Purity/Quality:

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Technology Process of 4-((1R,2R)-2-{[(4-bromobenzyl)oxy]methyl}cyclopropyl)piperidine-1-carbonitrile

There total 1 articles about 4-((1R,2R)-2-{[(4-bromobenzyl)oxy]methyl}cyclopropyl)piperidine-1-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 506-68-3
bromocyane

: 1416366-21-6
4-((1R,2R)-2-{[(4-bromobenzyl)oxy]methyl}cyclopropyl)piperidine trifluoroacetate

: 1416366-22-7
4-((1R,2R)-2-{[(4-bromobenzyl)oxy]methyl}cyclopropyl)piperidine-1-carbonitrile

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃;

Reference yield:

: 1416366-22-7
4-((1R,2R)-2-{[(4-bromobenzyl)oxy]methyl}cyclopropyl)piperidine-1-carbonitrile

: 20277-69-4
sodium methansulfinate

: 1416366-18-1
4-[(1R,2R)-2-({[4-(methylsulfonyl)benzyl]oxy}methyl)cyclopropyl]piperidine-carbonitrile

Guidance literature:: With N,N`-dimethylethylenediamine; copper(I) trifluoromethanesulfonate benzene complex; In dimethyl sulfoxide; at 120 ℃; Inert atmosphere; Sealed vial;

Reference yield:

: 1416366-22-7
4-((1R,2R)-2-{[(4-bromobenzyl)oxy]methyl}cyclopropyl)piperidine-1-carbonitrile

: 1416364-34-5
1-(3-isopropyl-1,2,4-oxadiazol-5-y)l-4-[(1R,2R)-2-({[4-(methylsulfonyl)benzyl]oxy}methyl)cyclopropyl]piperidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: N,N`-dimethylethylenediamine / copper(I) trifluoromethanesulfonate benzene complex / dimethyl sulfoxide / 120 °C / Inert atmosphere; Sealed vial

2.1: zinc(II) chloride / diethyl ether; tetrahydrofuran / 3 h / 20 °C

2.2: 1 h / 90 °C

With zinc(II) chloride; N,N`-dimethylethylenediamine; copper(I) trifluoromethanesulfonate benzene complex; In tetrahydrofuran; diethyl ether; dimethyl sulfoxide;