ethyl 3-(4-((2-(dimethylamino)ethyl)carbamoyl)-3-thienyl)-3-(4-fluorophenyl)-2-hydroxyacrylate

Base Information

• Chemical Name: ethyl 3-(4-((2-(dimethylamino)ethyl)carbamoyl)-3-thienyl)-3-(4-fluorophenyl)-2-hydroxyacrylate
• CAS No.: 1450742-90-1
• Molecular Formula: C₂₀H₂₃FN₂O₄S
• Molecular Weight: 406.478
• Mol file: 1450742-90-1.mol

Synonyms:ethyl 3-(4-((2-(dimethylamino)ethyl)carbamoyl)-3-thienyl)-3-(4-fluorophenyl)-2-hydroxyacrylate

Chemical Property of ethyl 3-(4-((2-(dimethylamino)ethyl)carbamoyl)-3-thienyl)-3-(4-fluorophenyl)-2-hydroxyacrylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 3-(4-((2-(dimethylamino)ethyl)carbamoyl)-3-thienyl)-3-(4-fluorophenyl)-2-hydroxyacrylate

There total 1 articles about ethyl 3-(4-((2-(dimethylamino)ethyl)carbamoyl)-3-thienyl)-3-(4-fluorophenyl)-2-hydroxyacrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

ethyl 7-(4-fluorophenyl)-4-oxo-4H-thieno[3,4-c]pyran-6-carboxylate (1450742-88-7) + N,N-dimethylethylenediamine (108-00-9) → ethyl 3-(4-((2-(dimethylamino)ethyl)carbamoyl)-3-thienyl)-3-(4-fluorophenyl)-2-hydroxyacrylate (1450742-90-1)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 18h;

DOI:10.1016/j.bmc.2013.05.067

Reference yield: 100.0%

ethyl 3-(4-((2-(dimethylamino)ethyl)carbamoyl)-3-thienyl)-3-(4-fluorophenyl)-2-hydroxyacrylate (1450742-90-1) → ethyl 5-(2-(dimethylamino)ethyl)-7-(4-fluorophenyl)-4-oxo-4,5-dihydrothieno[3,4-c]pyridine-6-carboxylate (1450742-92-3)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; at 120 ℃; for 2h;

DOI:10.1016/j.bmc.2013.05.067

Reference yield:

ethyl 3-(4-((2-(dimethylamino)ethyl)carbamoyl)-3-thienyl)-3-(4-fluorophenyl)-2-hydroxyacrylate (1450742-90-1) → 5-(2-(dimethylamino)ethyl)-7-(4-fluorophenyl)-4-oxo-4,5-dihydrothieno[3,4-c]pyridine-6-carboxylic acid (1450742-94-5)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / toluene / 2 h / 120 °C

2: sodium hydroxide / tetrahydrofuran; ethanol / 6 h / 80 °C

With toluene-4-sulfonic acid; sodium hydroxide; In tetrahydrofuran; ethanol; toluene;

DOI:10.1016/j.bmc.2013.05.067

upstream raw materials:

ethyl 7-(4-fluorophenyl)-4-oxo-4H-thieno[3,4-c]pyran-6-carboxylate

N,N-dimethylethylenediamine

Downstream raw materials:

5-(2-(dimethylamino)ethyl)-7-(4-fluorophenyl)-4-oxo-4,5-dihydrothieno[3,4-c]pyridine-6-carboxylic acid

ethyl 5-(2-(dimethylamino)ethyl)-7-(4-fluorophenyl)-4-oxo-4,5-dihydrothieno[3,4-c]pyridine-6-carboxylate

N-(3,4-dichlorobenzyl)-5-(2-(dimethylamino)ethyl)-7-(4-fluorophenyl)-N-methyl-4-oxo-4,5-dihydrothieno[3,4-c]pyridine-6-carboxamide

Refernces