(R)-2-((2,5-dichloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydriquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)benzyl)thio)-1-methyl-1H-imidazole-5-carboxylic acid

Base Information

Chemical Name:(R)-2-((2,5-dichloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydriquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)benzyl)thio)-1-methyl-1H-imidazole-5-carboxylic acid
CAS No.:1445983-27-6
Molecular Formula:C₂₈H₂₉Cl₂N₅O₃S₂
Molecular Weight:618.608
Hs Code.:

(R)-2-((2,5-dichloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydriquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)benzyl)thio)-1-methyl-1H-imidazole-5-carboxylic acid

Synonyms:(R)-2-((2,5-dichloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydriquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)benzyl)thio)-1-methyl-1H-imidazole-5-carboxylic acid

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Chemical Property of (R)-2-((2,5-dichloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydriquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)benzyl)thio)-1-methyl-1H-imidazole-5-carboxylic acid

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Technology Process of (R)-2-((2,5-dichloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydriquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)benzyl)thio)-1-methyl-1H-imidazole-5-carboxylic acid

There total 13 articles about (R)-2-((2,5-dichloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydriquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)benzyl)thio)-1-methyl-1H-imidazole-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1445985-54-5
(R)-methyl 2-((2,5-dichloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydriquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)benzyl)thio)-1-methyl-1H-imidazole-5-carboxylate

: 1445983-27-6
(R)-2-((2,5-dichloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydriquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)benzyl)thio)-1-methyl-1H-imidazole-5-carboxylic acid

Guidance literature:: With lithium hydroxide monohydrate; water; In tetrahydrofuran;

Reference yield:

: 1124-05-6
1,4-dichloro-2,5-dimethylbenzene

: 1445983-27-6
(R)-2-((2,5-dichloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydriquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)benzyl)thio)-1-methyl-1H-imidazole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: acetic acid; acetic anhydride; sulfuric acid; chromium(VI) oxide / 6 h / 0 - 20 °C

2: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane

3: triphenylphosphine; diethylazodicarboxylate / toluene / 3 h / 0 - 20 °C

4: lithium hydroxide monohydrate; water / tetrahydrofuran / 20 °C

With chromium(VI) oxide; lithium hydroxide monohydrate; sulfuric acid; water; acetic anhydride; sodium tris(acetoxy)borohydride; acetic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,2-dichloro-ethane; toluene;
DOI:10.1021/acs.jmedchem.8b00308

Reference yield:

: 46052-84-0
2,5-dichloroterephthalic dicarboxaldehyde

: 1445983-27-6
(R)-2-((2,5-dichloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydriquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)benzyl)thio)-1-methyl-1H-imidazole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane

2: triphenylphosphine; diethylazodicarboxylate / toluene / 3 h / 0 - 20 °C

3: lithium hydroxide monohydrate; water / tetrahydrofuran / 20 °C

With lithium hydroxide monohydrate; water; sodium tris(acetoxy)borohydride; acetic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,2-dichloro-ethane; toluene;
DOI:10.1021/acs.jmedchem.8b00308