(R)-methyl 2-((2,5-dichloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydriquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)benzyl)thio)-1-methyl-1H-imidazole-5-carboxylate

Base Information

Chemical Name:(R)-methyl 2-((2,5-dichloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydriquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)benzyl)thio)-1-methyl-1H-imidazole-5-carboxylate
CAS No.:1445985-54-5
Molecular Formula:C₂₉H₃₁Cl₂N₅O₃S₂
Molecular Weight:632.635
Hs Code.:

(R)-methyl 2-((2,5-dichloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydriquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)benzyl)thio)-1-methyl-1H-imidazole-5-carboxylate

Synonyms:(R)-methyl 2-((2,5-dichloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydriquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)benzyl)thio)-1-methyl-1H-imidazole-5-carboxylate

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Chemical Property of (R)-methyl 2-((2,5-dichloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydriquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)benzyl)thio)-1-methyl-1H-imidazole-5-carboxylate

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Technology Process of (R)-methyl 2-((2,5-dichloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydriquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)benzyl)thio)-1-methyl-1H-imidazole-5-carboxylate

There total 12 articles about (R)-methyl 2-((2,5-dichloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydriquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)benzyl)thio)-1-methyl-1H-imidazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1445983-24-3
(R)-(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)(3-(2,5-dichloro-4-(hydroxymethyl)benzyl)thiazolidin-4-yl)methanone

: 68892-07-9
1-methyl-5-carbomethoxy-2-thio-imidazole

: 1445985-54-5
(R)-methyl 2-((2,5-dichloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydriquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)benzyl)thio)-1-methyl-1H-imidazole-5-carboxylate

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In toluene; at 20 ℃; for 3h;

Reference yield:

: 1124-05-6
1,4-dichloro-2,5-dimethylbenzene

: 1445985-54-5
(R)-methyl 2-((2,5-dichloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydriquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)benzyl)thio)-1-methyl-1H-imidazole-5-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid; acetic anhydride; sulfuric acid; chromium(VI) oxide / 6 h / 0 - 20 °C

2: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane

3: triphenylphosphine; diethylazodicarboxylate / toluene / 3 h / 0 - 20 °C

With chromium(VI) oxide; sulfuric acid; acetic anhydride; sodium tris(acetoxy)borohydride; acetic acid; triphenylphosphine; diethylazodicarboxylate; In 1,2-dichloro-ethane; toluene;
DOI:10.1021/acs.jmedchem.8b00308

Reference yield:

: 46052-84-0
2,5-dichloroterephthalic dicarboxaldehyde

: 1445985-54-5
(R)-methyl 2-((2,5-dichloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydriquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)benzyl)thio)-1-methyl-1H-imidazole-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane

2: triphenylphosphine; diethylazodicarboxylate / toluene / 3 h / 0 - 20 °C

With sodium tris(acetoxy)borohydride; acetic acid; triphenylphosphine; diethylazodicarboxylate; In 1,2-dichloro-ethane; toluene;
DOI:10.1021/acs.jmedchem.8b00308