2-(1-(tert-butyl)-5-(4-methoxyphenyl)-1H-pyrazol-4-yl)thiazole-4-carbaldehyde

Base Information

Chemical Name:2-(1-(tert-butyl)-5-(4-methoxyphenyl)-1H-pyrazol-4-yl)thiazole-4-carbaldehyde
CAS No.:1421850-05-6
Molecular Formula:C₁₈H₁₉N₃O₂S
Molecular Weight:341.434
Hs Code.:

Synonyms:2-(1-(tert-butyl)-5-(4-methoxyphenyl)-1H-pyrazol-4-yl)thiazole-4-carbaldehyde

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Chemical Property of 2-(1-(tert-butyl)-5-(4-methoxyphenyl)-1H-pyrazol-4-yl)thiazole-4-carbaldehyde

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Technology Process of 2-(1-(tert-butyl)-5-(4-methoxyphenyl)-1H-pyrazol-4-yl)thiazole-4-carbaldehyde

There total 7 articles about 2-(1-(tert-butyl)-5-(4-methoxyphenyl)-1H-pyrazol-4-yl)thiazole-4-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1421850-04-5
(2-(1-(tert-butyl)-5-(4-methoxyphenyl)-1H-pyrazol-4-yl)thiazol-4-yl)methanol

: 1421850-05-6
2-(1-(tert-butyl)-5-(4-methoxyphenyl)-1H-pyrazol-4-yl)thiazole-4-carbaldehyde

Guidance literature:: With sulfur trioxide pyridine complex; In dimethyl sulfoxide; at 20 ℃; for 14h;

Reference yield:

: 2881-83-6
ethyl 4-methoxybenzoylacetate

: 1421850-05-6
2-(1-(tert-butyl)-5-(4-methoxyphenyl)-1H-pyrazol-4-yl)thiazole-4-carbaldehyde

Guidance literature:: Multi-step reaction with 7 steps

1.1: toluene / 14 h / 90 °C

1.2: 20 h / 80 °C

2.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 1 h / 20 °C

3.1: thionyl chloride / toluene / 2.5 h / 100 °C

3.2: 14 h / 20 °C

4.1: Lawessons reagent / tetrahydrofuran / 0.33 h / 60 °C

5.1: ethanol / 14 h / 90 °C

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C

7.1: sulfur trioxide pyridine complex / dimethyl sulfoxide / 14 h / 20 °C

With Lawessons reagent; lithium aluminium tetrahydride; thionyl chloride; water; sulfur trioxide pyridine complex; sodium hydroxide; In tetrahydrofuran; ethanol; dimethyl sulfoxide; toluene;

Reference yield:

: 1421848-81-8
1-tert-butyl-5-(4-methoxyphenyl)-1H-pyrazole-4-carboxylic acid

: 1421850-05-6
2-(1-(tert-butyl)-5-(4-methoxyphenyl)-1H-pyrazol-4-yl)thiazole-4-carbaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1.1: thionyl chloride / toluene / 2.5 h / 100 °C

1.2: 14 h / 20 °C

2.1: Lawessons reagent / tetrahydrofuran / 0.33 h / 60 °C

3.1: ethanol / 14 h / 90 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 °C

5.1: sulfur trioxide pyridine complex / dimethyl sulfoxide / 14 h / 20 °C

With Lawessons reagent; lithium aluminium tetrahydride; thionyl chloride; sulfur trioxide pyridine complex; In tetrahydrofuran; ethanol; dimethyl sulfoxide; toluene;