2,6-diazido-9-(3-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purine

Base Information

• Chemical Name: 2,6-diazido-9-(3-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purine
• CAS No.: 103885-01-4
• Molecular Formula: C₁₉H₁₅FN₁₀O₅
• Molecular Weight: 482.391
• Mol file: 103885-01-4.mol

Synonyms:2,6-diazido-9-(3-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purine

Chemical Property of 2,6-diazido-9-(3-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,6-diazido-9-(3-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purine

There total 4 articles about 2,6-diazido-9-(3-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

2,6-dichloro-9-(3-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purine (103884-99-7) → 2,6-diazido-9-(3-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purine (103885-01-4)

Guidance literature:

With sodium azide; In ethanol; for 0.5h; Heating;

DOI:10.1021/jm00161a041

Reference yield:

1,3-di-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-D-arabinofuranosyl bromide (56632-81-6) → 2,6-diazido-9-(3-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purine (103885-01-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 4A molecular sieves / 1,2-dichloro-ethane / 16 h / Heating

2: 72 percent / aq. NaN₃ / ethanol / 0.5 h / Heating

With sodium azide; 4 A molecular sieve; In ethanol; 1,2-dichloro-ethane;

DOI:10.1021/jm00161a041

Reference yield:

2,6 dichloropurine (5451-40-1) → 2,6-diazido-9-(3-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purine (103885-01-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 4A molecular sieves / 1,2-dichloro-ethane / 16 h / Heating

2: 72 percent / aq. NaN₃ / ethanol / 0.5 h / Heating

With sodium azide; 4 A molecular sieve; In ethanol; 1,2-dichloro-ethane;

DOI:10.1021/jm00161a041

upstream raw materials:

2,6-dichloro-9-(3-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purine

1,3-di-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-D-arabinofuranosyl bromide

2,6 dichloropurine

1,3-di-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinose

Downstream raw materials:

9-(3-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purine-2,6-diamine

9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-guanine

9-(2’-deoxy-2’-fluoro-β-D-arabinofuranos-1’-yl)-2-amino-6-aminopurine