2-methyl-2-(4-{3-[1-(4-methylbenzyl)-5-oxo-4,5-dihydro-1H-[1,2,4]triazol-3-yl]propyl}phenoxy)propionic acid methyl ester

Base Information

Chemical Name:2-methyl-2-(4-{3-[1-(4-methylbenzyl)-5-oxo-4,5-dihydro-1H-[1,2,4]triazol-3-yl]propyl}phenoxy)propionic acid methyl ester
CAS No.:425674-22-2
Molecular Formula:C₂₄H₂₉N₃O₄
Molecular Weight:423.512
Hs Code.:

Synonyms:2-methyl-2-(4-{3-[1-(4-methylbenzyl)-5-oxo-4,5-dihydro-1H-[1,2,4]triazol-3-yl]propyl}phenoxy)propionic acid methyl ester

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Chemical Property of 2-methyl-2-(4-{3-[1-(4-methylbenzyl)-5-oxo-4,5-dihydro-1H-[1,2,4]triazol-3-yl]propyl}phenoxy)propionic acid methyl ester

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Technology Process of 2-methyl-2-(4-{3-[1-(4-methylbenzyl)-5-oxo-4,5-dihydro-1H-[1,2,4]triazol-3-yl]propyl}phenoxy)propionic acid methyl ester

There total 8 articles about 2-methyl-2-(4-{3-[1-(4-methylbenzyl)-5-oxo-4,5-dihydro-1H-[1,2,4]triazol-3-yl]propyl}phenoxy)propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 425674-21-1
2-(4-{3-[4-(2,4-dimethoxybenzyl)-1-(4-methylbenzyl)-5-oxo-4,5-dihydro-1H-[1,2,4]triazol-3-yl]propyl}phenoxy)-2-methylpropionic acid methyl ester

: 425674-22-2
2-methyl-2-(4-{3-[1-(4-methylbenzyl)-5-oxo-4,5-dihydro-1H-[1,2,4]triazol-3-yl]propyl}phenoxy)propionic acid methyl ester

Guidance literature:: 2-(4-{3-[4-(2,4-dimethoxybenzyl)-1-(4-methylbenzyl)-5-oxo-4,5-dihydro-1H-[1,2,4]triazol-3-yl]propyl}phenoxy)-2-methylpropionic acid methyl ester; With hydrogen bromide; acetic acid; at 20 ℃; for 30h;

With methanol; sulfuric acid; at 20 ℃; for 18h;
DOI:10.1021/jm034173l

Reference yield:

: 20637-08-5
4-(4-methoxyphenyl)butyric acid methyl ester

: 425674-22-2
2-methyl-2-(4-{3-[1-(4-methylbenzyl)-5-oxo-4,5-dihydro-1H-[1,2,4]triazol-3-yl]propyl}phenoxy)propionic acid methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: BBr₃ / CH₂Cl₂ / 1 h / 0 °C

2.1: 27 g / K₂CO₃; MgSO₄ / dimethylformamide / 75 °C

3.1: hydrazine hydrate / methanol / 20 °C

4.1: 67 percent / CH₂Cl₂ / 2 h / 20 °C

5.1: KOH / methanol / 48 h / Heating

6.1: H₂SO₄ / 4 h / 35 °C

7.1: K₂CO₃ / dimethylformamide / 18 h / 20 °C

8.1: HBr; AcOH / 30 h / 20 °C

8.2: 1.51 g / MeOH; H₂SO₄ / 18 h / 20 °C

With potassium hydroxide; sulfuric acid; hydrogen bromide; boron tribromide; magnesium sulfate; potassium carbonate; hydrazine hydrate; acetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm034173l

Reference yield:

: 22320-10-1
methyl 4-(4-hydroxyphenyl)butanoate

: 425674-22-2
2-methyl-2-(4-{3-[1-(4-methylbenzyl)-5-oxo-4,5-dihydro-1H-[1,2,4]triazol-3-yl]propyl}phenoxy)propionic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: 27 g / K₂CO₃; MgSO₄ / dimethylformamide / 75 °C

2.1: hydrazine hydrate / methanol / 20 °C

3.1: 67 percent / CH₂Cl₂ / 2 h / 20 °C

4.1: KOH / methanol / 48 h / Heating

5.1: H₂SO₄ / 4 h / 35 °C

6.1: K₂CO₃ / dimethylformamide / 18 h / 20 °C

7.1: HBr; AcOH / 30 h / 20 °C

7.2: 1.51 g / MeOH; H₂SO₄ / 18 h / 20 °C

With potassium hydroxide; sulfuric acid; hydrogen bromide; magnesium sulfate; potassium carbonate; hydrazine hydrate; acetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm034173l