1-[(7R,8aS)-7-[(5-cyclopropylpyrazin-2-yl)oxy]hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-2-methoxy-2-[3-(trifluoromethyl)phenyl]ethanone

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Chemical Name:1-[(7R,8aS)-7-[(5-cyclopropylpyrazin-2-yl)oxy]hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-2-methoxy-2-[3-(trifluoromethyl)phenyl]ethanone
CAS No.:1429296-22-9
Molecular Formula:C₂₄H₂₇F₃N₄O₃
Molecular Weight:476.499
Hs Code.:

Synonyms:1-[(7R,8aS)-7-[(5-cyclopropylpyrazin-2-yl)oxy]hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-2-methoxy-2-[3-(trifluoromethyl)phenyl]ethanone

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Chemical Property of 1-[(7R,8aS)-7-[(5-cyclopropylpyrazin-2-yl)oxy]hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-2-methoxy-2-[3-(trifluoromethyl)phenyl]ethanone

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Technology Process of 1-[(7R,8aS)-7-[(5-cyclopropylpyrazin-2-yl)oxy]hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-2-methoxy-2-[3-(trifluoromethyl)phenyl]ethanone

There total 6 articles about 1-[(7R,8aS)-7-[(5-cyclopropylpyrazin-2-yl)oxy]hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-2-methoxy-2-[3-(trifluoromethyl)phenyl]ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1429296-06-9
1-[(7R,8aS)-7-[(5-cyclopropylpyrazin-2-yl)oxy]hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-2-hydroxy-2-[3-(trifluoromethyl)phenyl]ethanone

: 74-88-4
methyl iodide

: 1429296-22-9
1-[(7R,8aS)-7-[(5-cyclopropylpyrazin-2-yl)oxy]hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-2-methoxy-2-[3-(trifluoromethyl)phenyl]ethanone

Guidance literature:: 1-[(7R,8aS)-7-[(5-cyclopropylpyrazin-2-yl)oxy]hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-2-hydroxy-2-[3-(trifluoromethyl)phenyl]ethanone; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.166667h;

methyl iodide; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 1.5h;

Reference yield:

: 132715-17-4
(2S,4R)-methyl 1-(2-chloroacetyl)-4-hydroxypyrrolidine-2-carboxylate

: 1429296-22-9
1-[(7R,8aS)-7-[(5-cyclopropylpyrazin-2-yl)oxy]hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-2-methoxy-2-[3-(trifluoromethyl)phenyl]ethanone

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / 2-ethoxy-ethanol / 12 h / Reflux

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 78 h / 15 - 65 °C

3.1: potassium tert-butylate / tetrahydrofuran / 48 h / 20 °C

4.1: 20% palladium hydroxide-activated charcoal; hydrogen / tetrahydrofuran / 16 h / 50 °C / 1551.49 Torr

5.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; 4-methyl-morpholine / N,N-dimethyl-formamide / 1.5 h / 20 °C

6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 20 °C

6.2: 1.5 h / 20 °C

With 4-methyl-morpholine; lithium aluminium tetrahydride; 20% palladium hydroxide-activated charcoal; potassium tert-butylate; hydrogen; sodium hydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In tetrahydrofuran; 2-ethoxy-ethanol; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 132714-97-7
(7R,8aS)-2-benzyl-7-hydroxyhexahydropyrrolo[1,2-a]pyrazine-1,4-dione

: 1429296-22-9
1-[(7R,8aS)-7-[(5-cyclopropylpyrazin-2-yl)oxy]hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-2-methoxy-2-[3-(trifluoromethyl)phenyl]ethanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 78 h / 15 - 65 °C

2.1: potassium tert-butylate / tetrahydrofuran / 48 h / 20 °C

3.1: 20% palladium hydroxide-activated charcoal; hydrogen / tetrahydrofuran / 16 h / 50 °C / 1551.49 Torr

4.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; 4-methyl-morpholine / N,N-dimethyl-formamide / 1.5 h / 20 °C

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 20 °C

5.2: 1.5 h / 20 °C

With 4-methyl-morpholine; lithium aluminium tetrahydride; 20% palladium hydroxide-activated charcoal; potassium tert-butylate; hydrogen; sodium hydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;