2-[2-(3-bromo-phenyl)-2R-tert-butoxycarbonyl-amino-propyl]-2H-pyrazole-3-carboxylic acid ethyl ester

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Chemical Name:2-[2-(3-bromo-phenyl)-2R-tert-butoxycarbonyl-amino-propyl]-2H-pyrazole-3-carboxylic acid ethyl ester
CAS No.:1397683-34-9
Molecular Formula:C₂₀H₂₆BrN₃O₄
Molecular Weight:452.348
Hs Code.:

Synonyms:2-[2-(3-bromo-phenyl)-2R-tert-butoxycarbonyl-amino-propyl]-2H-pyrazole-3-carboxylic acid ethyl ester

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Chemical Property of 2-[2-(3-bromo-phenyl)-2R-tert-butoxycarbonyl-amino-propyl]-2H-pyrazole-3-carboxylic acid ethyl ester

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Technology Process of 2-[2-(3-bromo-phenyl)-2R-tert-butoxycarbonyl-amino-propyl]-2H-pyrazole-3-carboxylic acid ethyl ester

There total 8 articles about 2-[2-(3-bromo-phenyl)-2R-tert-butoxycarbonyl-amino-propyl]-2H-pyrazole-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 1352419-84-1
(R)-[3-(tert-butyloxycarbonyl)]-4-(3-bromo-phenyl)-4-methyl-[1,1,3]oxathiazolidine-2,2-dioxide

: 21056-77-9
2H-pyrazole-3-carboxylic acid ethyl ester

: 1397683-34-9
2-[2-(3-bromo-phenyl)-2R-tert-butoxycarbonyl-amino-propyl]-2H-pyrazole-3-carboxylic acid ethyl ester

Guidance literature:: (R)-[3-(tert-butyloxycarbonyl)]-4-(3-bromo-phenyl)-4-methyl-[1,1,3]oxathiazolidine-2,2-dioxide; 2H-pyrazole-3-carboxylic acid ethyl ester; With caesium carbonate; In dimethyl sulfoxide; at 20 - 110 ℃; for 3.5h;

With citric acid; In dichloromethane; dimethyl sulfoxide; for 2h;

Reference yield:

: 2142-63-4
1-(3-Bromophenyl)ethanone

: 1397683-34-9
2-[2-(3-bromo-phenyl)-2R-tert-butoxycarbonyl-amino-propyl]-2H-pyrazole-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: ammonium chloride / ammonia; methanol / 96 h / 20 °C

2.1: hydrogenchloride / 96 h / Reflux

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / -15 - 0 °C

3.2: 20 °C

4.1: Chiralpak_.(R). Daicel AD / carbon dioxide; isopropylamine; methanol

5.1: sodium hydrogencarbonate / tetrahydrofuran / 15.17 h / 0 - 20 °C

5.2: pH 1 - 2 / Cooling with ice

6.1: thionyl chloride / acetonitrile / 0.5 h / -40 °C / Inert atmosphere

6.2: 64 h / 20 °C

7.1: sodium periodate / ruthenium trichloride / acetonitrile; water / 2 h / 0 - 20 °C

8.1: caesium carbonate / dimethyl sulfoxide / 3.5 h / 20 - 110 °C

8.2: 2 h

With hydrogenchloride; sodium periodate; lithium aluminium tetrahydride; thionyl chloride; sodium hydrogencarbonate; ammonium chloride; caesium carbonate; ruthenium trichloride; In tetrahydrofuran; methanol; carbon dioxide; ammonia; water; dimethyl sulfoxide; isopropylamine; acetonitrile;

Reference yield:

: 1352419-82-9
(R)-tert-butyl N-[1-(3-bromophenyl)-2-hydroxy-1-methylethyl]carbamate

: 1397683-34-9
2-[2-(3-bromo-phenyl)-2R-tert-butoxycarbonyl-amino-propyl]-2H-pyrazole-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / acetonitrile / 0.5 h / -40 °C / Inert atmosphere

1.2: 64 h / 20 °C

2.1: sodium periodate / ruthenium trichloride / acetonitrile; water / 2 h / 0 - 20 °C

3.1: caesium carbonate / dimethyl sulfoxide / 3.5 h / 20 - 110 °C

3.2: 2 h

With sodium periodate; thionyl chloride; caesium carbonate; ruthenium trichloride; In water; dimethyl sulfoxide; acetonitrile;