5-benzyloxy-2-(4-benzyloxy-phenyl)-3-methyl-1-[4-(2-piperidin-1-yl-ethoxy)-benzyl]-1H-indole

Base Information

Chemical Name:5-benzyloxy-2-(4-benzyloxy-phenyl)-3-methyl-1-[4-(2-piperidin-1-yl-ethoxy)-benzyl]-1H-indole
CAS No.:198480-20-5
Molecular Formula:C₄₃H₄₄N₂O₃
Molecular Weight:636.834
Hs Code.:

Synonyms:5-benzyloxy-2-(4-benzyloxy-phenyl)-3-methyl-1-[4-(2-piperidin-1-yl-ethoxy)-benzyl]-1H-indole

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Chemical Property of 5-benzyloxy-2-(4-benzyloxy-phenyl)-3-methyl-1-[4-(2-piperidin-1-yl-ethoxy)-benzyl]-1H-indole

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Technology Process of 5-benzyloxy-2-(4-benzyloxy-phenyl)-3-methyl-1-[4-(2-piperidin-1-yl-ethoxy)-benzyl]-1H-indole

There total 10 articles about 5-benzyloxy-2-(4-benzyloxy-phenyl)-3-methyl-1-[4-(2-piperidin-1-yl-ethoxy)-benzyl]-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 35081-45-9
1-<4-(benzyloxy)phenyl>-2-bromo-1-propanone

: 198480-20-5
5-benzyloxy-2-(4-benzyloxy-phenyl)-3-methyl-1-[4-(2-piperidin-1-yl-ethoxy)-benzyl]-1H-indole

Guidance literature:: Multi-step reaction with 5 steps

1.1: 51 percent / Et₃N / dimethylformamide / Heating

2.1: sodium hydride / dimethylformamide / 0.33 h / 0 °C

2.2: 59 percent / dimethylformamide / 18 h / 20 °C

3.1: 78 percent / LiAlH₄ / tetrahydrofuran / 0.5 h / 0 °C

4.1: 87 percent / CBr₄; Ph₃P / tetrahydrofuran / 3 h / 20 °C

5.1: 2.7 g / tetrahydrofuran / 5 h / Heating

With lithium aluminium tetrahydride; carbon tetrabromide; sodium hydride; triethylamine; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide; 1.1: Bischler synthesis;
DOI:10.1021/jm010086m

Reference yield:

: 623-05-2
(4-hydroxyphenyl)methanol

: 198480-20-5
5-benzyloxy-2-(4-benzyloxy-phenyl)-3-methyl-1-[4-(2-piperidin-1-yl-ethoxy)-benzyl]-1H-indole

Guidance literature:: Multi-step reaction with 6 steps

1.1: K₂CO₃

2.1: SOCl₂ / tetrahydrofuran

3.1: sodium hydride / dimethylformamide / 0.33 h / 0 °C

3.2: 59 percent / dimethylformamide / 18 h / 20 °C

4.1: 78 percent / LiAlH₄ / tetrahydrofuran / 0.5 h / 0 °C

5.1: 87 percent / CBr₄; Ph₃P / tetrahydrofuran / 3 h / 20 °C

6.1: 2.7 g / tetrahydrofuran / 5 h / Heating

With lithium aluminium tetrahydride; thionyl chloride; carbon tetrabromide; sodium hydride; potassium carbonate; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm010086m

Reference yield:

: 51388-20-6
4-benzyloxyaniline hydrochloride

: 198480-20-5
5-benzyloxy-2-(4-benzyloxy-phenyl)-3-methyl-1-[4-(2-piperidin-1-yl-ethoxy)-benzyl]-1H-indole

Guidance literature:: Multi-step reaction with 5 steps

1.1: 51 percent / Et₃N / dimethylformamide / Heating

2.1: sodium hydride / dimethylformamide / 0.33 h / 0 °C

2.2: 59 percent / dimethylformamide / 18 h / 20 °C

3.1: 78 percent / LiAlH₄ / tetrahydrofuran / 0.5 h / 0 °C

4.1: 87 percent / CBr₄; Ph₃P / tetrahydrofuran / 3 h / 20 °C

5.1: 2.7 g / tetrahydrofuran / 5 h / Heating

With lithium aluminium tetrahydride; carbon tetrabromide; sodium hydride; triethylamine; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide; 1.1: Bischler synthesis;
DOI:10.1021/jm010086m