5-benzyloxy-2-(4-benzyloxy-phenyl)-1-[4-(2-bromo-ethoxy)-benzyl]-3-methyl-1H-indole

Base Information

Chemical Name:5-benzyloxy-2-(4-benzyloxy-phenyl)-1-[4-(2-bromo-ethoxy)-benzyl]-3-methyl-1H-indole
CAS No.:198480-07-8
Molecular Formula:C₃₈H₃₄BrNO₃
Molecular Weight:632.597
Hs Code.:

Synonyms:5-benzyloxy-2-(4-benzyloxy-phenyl)-1-[4-(2-bromo-ethoxy)-benzyl]-3-methyl-1H-indole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-benzyloxy-2-(4-benzyloxy-phenyl)-1-[4-(2-bromo-ethoxy)-benzyl]-3-methyl-1H-indole

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of 5-benzyloxy-2-(4-benzyloxy-phenyl)-1-[4-(2-bromo-ethoxy)-benzyl]-3-methyl-1H-indole

There total 9 articles about 5-benzyloxy-2-(4-benzyloxy-phenyl)-1-[4-(2-bromo-ethoxy)-benzyl]-3-methyl-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 198479-95-7
2-(4-((5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-methyl-1H-indol-1-yl)methyl)phenoxy)ethanol

: 198480-07-8
5-benzyloxy-2-(4-benzyloxy-phenyl)-1-[4-(2-bromo-ethoxy)-benzyl]-3-methyl-1H-indole

Guidance literature:: With carbon tetrabromide; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 3h;
DOI:10.1021/jm010086m

Reference yield:

: 103258-64-6
ethyl 2-(4-hydroxymethylphenoxy)acetate

: 198480-07-8
5-benzyloxy-2-(4-benzyloxy-phenyl)-1-[4-(2-bromo-ethoxy)-benzyl]-3-methyl-1H-indole

Guidance literature:: Multi-step reaction with 4 steps

1.1: SOCl₂ / tetrahydrofuran

2.1: sodium hydride / dimethylformamide / 0.33 h / 0 °C

2.2: 59 percent / dimethylformamide / 18 h / 20 °C

3.1: 78 percent / LiAlH₄ / tetrahydrofuran / 0.5 h / 0 °C

4.1: 87 percent / CBr₄; Ph₃P / tetrahydrofuran / 3 h / 20 °C

With lithium aluminium tetrahydride; thionyl chloride; carbon tetrabromide; sodium hydride; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm010086m

Reference yield:

: 80494-75-3
ethyl [p-(chloromethyl)phenoxy]acetate

: 198480-07-8
5-benzyloxy-2-(4-benzyloxy-phenyl)-1-[4-(2-bromo-ethoxy)-benzyl]-3-methyl-1H-indole

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / dimethylformamide / 0.33 h / 0 °C

1.2: 59 percent / dimethylformamide / 18 h / 20 °C

2.1: 78 percent / LiAlH₄ / tetrahydrofuran / 0.5 h / 0 °C

3.1: 87 percent / CBr₄; Ph₃P / tetrahydrofuran / 3 h / 20 °C

With lithium aluminium tetrahydride; carbon tetrabromide; sodium hydride; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm010086m