4-(4-(2-amino-3-(5-(benzyloxy)pyridin-2-yl)propanamido)phenyl)-N-hydroxybutanamide

Base Information

Chemical Name:4-(4-(2-amino-3-(5-(benzyloxy)pyridin-2-yl)propanamido)phenyl)-N-hydroxybutanamide
CAS No.:1351934-95-6
Molecular Formula:C₂₅H₂₈N₄O₄
Molecular Weight:448.522
Hs Code.:

Synonyms:4-(4-(2-amino-3-(5-(benzyloxy)pyridin-2-yl)propanamido)phenyl)-N-hydroxybutanamide

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Chemical Property of 4-(4-(2-amino-3-(5-(benzyloxy)pyridin-2-yl)propanamido)phenyl)-N-hydroxybutanamide

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Technology Process of 4-(4-(2-amino-3-(5-(benzyloxy)pyridin-2-yl)propanamido)phenyl)-N-hydroxybutanamide

There total 5 articles about 4-(4-(2-amino-3-(5-(benzyloxy)pyridin-2-yl)propanamido)phenyl)-N-hydroxybutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1350618-43-7
R(-)-tert-butyl N-{2-[5-(benzyloxy)pyridin-2-yl]-1-({4-[3-(hydroxycarbamoyl)propyl]phenyl}carbamoyl)ethyl}carbamate

: 1351934-95-6
4-(4-(2-amino-3-(5-(benzyloxy)pyridin-2-yl)propanamido)phenyl)-N-hydroxybutanamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 4h;

Reference yield:

: 20637-09-6
methyl 4-(4-aminophenyl)butanoate

: 1351934-95-6
4-(4-(2-amino-3-(5-(benzyloxy)pyridin-2-yl)propanamido)phenyl)-N-hydroxybutanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 2 h / 20 °C

2.1: water; lithium hydroxide / tetrahydrofuran / 2 h / 60 °C

2.2: pH 2 / Acidic conditions

3.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 0.5 h / 0 °C

3.2: 0.5 h / 0 - 20 °C

4.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

With water; chloroformic acid ethyl ester; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1350618-54-0
(R)-methyl 4-(4-(3-(5-(benzyloxy)pyridin-2-yl)-2-(tert-butoxycarbonylamino)propanamido)phenyl)butanoate

: 1351934-95-6
4-(4-(2-amino-3-(5-(benzyloxy)pyridin-2-yl)propanamido)phenyl)-N-hydroxybutanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: water; lithium hydroxide / tetrahydrofuran / 2 h / 60 °C

1.2: pH 2 / Acidic conditions

2.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 0.5 h / 0 °C

2.2: 0.5 h / 0 - 20 °C

3.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

With water; chloroformic acid ethyl ester; triethylamine; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; dichloromethane;