(R)-methyl 4-(4-(3-(5-(benzyloxy)pyridin-2-yl)-2-(tert-butoxycarbonylamino)propanamido)phenyl)butanoate

Base Information

Chemical Name:(R)-methyl 4-(4-(3-(5-(benzyloxy)pyridin-2-yl)-2-(tert-butoxycarbonylamino)propanamido)phenyl)butanoate
CAS No.:1350618-54-0
Molecular Formula:C₃₁H₃₇N₃O₆
Molecular Weight:547.651
Hs Code.:

Synonyms:(R)-methyl 4-(4-(3-(5-(benzyloxy)pyridin-2-yl)-2-(tert-butoxycarbonylamino)propanamido)phenyl)butanoate

Suppliers and Price of (R)-methyl 4-(4-(3-(5-(benzyloxy)pyridin-2-yl)-2-(tert-butoxycarbonylamino)propanamido)phenyl)butanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-methyl 4-(4-(3-(5-(benzyloxy)pyridin-2-yl)-2-(tert-butoxycarbonylamino)propanamido)phenyl)butanoate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (R)-methyl 4-(4-(3-(5-(benzyloxy)pyridin-2-yl)-2-(tert-butoxycarbonylamino)propanamido)phenyl)butanoate

There total 2 articles about (R)-methyl 4-(4-(3-(5-(benzyloxy)pyridin-2-yl)-2-(tert-butoxycarbonylamino)propanamido)phenyl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1350618-62-0
R-3-(5-(benzyloxy)pyridine-2-yl)-2-(tert-butoxycarbonylamino)propanoic acid

: 20637-09-6
methyl 4-(4-aminophenyl)butanoate

: 1350618-54-0
(R)-methyl 4-(4-(3-(5-(benzyloxy)pyridin-2-yl)-2-(tert-butoxycarbonylamino)propanamido)phenyl)butanoate

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 5600-62-4
4-(4-nitrophenyl)butanoic acid

: 1350618-54-0
(R)-methyl 4-(4-(3-(5-(benzyloxy)pyridin-2-yl)-2-(tert-butoxycarbonylamino)propanamido)phenyl)butanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / 12 h / Reflux

1.2: 4 h / 20 °C

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 2 h / 20 °C

With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;

Reference yield:

: 1350618-54-0
(R)-methyl 4-(4-(3-(5-(benzyloxy)pyridin-2-yl)-2-(tert-butoxycarbonylamino)propanamido)phenyl)butanoate

: 1350618-44-8
tert-butyl-1-(4-(4-(hydroxyamino)-4-oxobutyl)phenylamino)-3-(5-hydroxypyridin-2-yl)-1-oxopropan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: water; lithium hydroxide / tetrahydrofuran / 2 h / 60 °C

1.2: pH 2

2.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 0.5 h / 0 °C

2.2: 0.5 h / 20 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol / 4 h / 20 °C

With water; hydrogen; chloroformic acid ethyl ester; triethylamine; lithium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol;