R(-)-tert-butyl N-{2-[5-(benzyloxy)pyridin-2-yl]-1-({4-[3-(hydroxycarbamoyl)propyl]phenyl}carbamoyl)ethyl}carbamate

Base Information

Chemical Name:R(-)-tert-butyl N-{2-[5-(benzyloxy)pyridin-2-yl]-1-({4-[3-(hydroxycarbamoyl)propyl]phenyl}carbamoyl)ethyl}carbamate
CAS No.:1350618-43-7
Molecular Formula:C₃₀H₃₆N₄O₆
Molecular Weight:548.639
Hs Code.:

Synonyms:R(-)-tert-butyl N-{2-[5-(benzyloxy)pyridin-2-yl]-1-({4-[3-(hydroxycarbamoyl)propyl]phenyl}carbamoyl)ethyl}carbamate

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Chemical Property of R(-)-tert-butyl N-{2-[5-(benzyloxy)pyridin-2-yl]-1-({4-[3-(hydroxycarbamoyl)propyl]phenyl}carbamoyl)ethyl}carbamate

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Technology Process of R(-)-tert-butyl N-{2-[5-(benzyloxy)pyridin-2-yl]-1-({4-[3-(hydroxycarbamoyl)propyl]phenyl}carbamoyl)ethyl}carbamate

There total 9 articles about R(-)-tert-butyl N-{2-[5-(benzyloxy)pyridin-2-yl]-1-({4-[3-(hydroxycarbamoyl)propyl]phenyl}carbamoyl)ethyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1350618-55-1
(R)-4-(4-(3-(5-(benzyloxy)pyridin-2-yl)-2-(tert-butoxycarbonylamino)propanamido)phenyl)butanoic acid

: 1350618-43-7
R(-)-tert-butyl N-{2-[5-(benzyloxy)pyridin-2-yl]-1-({4-[3-(hydroxycarbamoyl)propyl]phenyl}carbamoyl)ethyl}carbamate

Guidance literature:: (R)-4-(4-(3-(5-(benzyloxy)pyridin-2-yl)-2-(tert-butoxycarbonylamino)propanamido)phenyl)butanoic acid; With chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; at 0 ℃; for 0.5h;

With hydroxylamine hydrochloride; potassium hydroxide; In tetrahydrofuran; methanol; at 0 - 20 ℃; for 0.5h;

Reference yield:

: tert-butyl N-{2-[5-(benzyloxy)pyridin-2-yl]-1-({4-[3-(hydroxycarbamoyl)propyl]phenyl}carbamoyl)ethyl}carbamate

: 1350618-43-7
R(-)-tert-butyl N-{2-[5-(benzyloxy)pyridin-2-yl]-1-({4-[3-(hydroxycarbamoyl)propyl]phenyl}carbamoyl)ethyl}carbamate

: S(+)-tert-butyl N-{2-[5-(benzyloxy)pyridin-2-yl]-1-({4-[3-(hydroxycarbamoyl)propyl]phenyl}carbamoyl)ethyl}carbamate

Guidance literature:: With semi-Chiralpak AD HPLC; In water; acetonitrile; Resolution of racemate;

Reference yield:

: 20637-09-6
methyl 4-(4-aminophenyl)butanoate

: 1350618-43-7
R(-)-tert-butyl N-{2-[5-(benzyloxy)pyridin-2-yl]-1-({4-[3-(hydroxycarbamoyl)propyl]phenyl}carbamoyl)ethyl}carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 2 h / 20 °C

2.1: water; lithium hydroxide / tetrahydrofuran / 2 h / 60 °C

2.2: pH 2 / Acidic conditions

3.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 0.5 h / 0 °C

3.2: 0.5 h / 0 - 20 °C

With water; chloroformic acid ethyl ester; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide; In tetrahydrofuran; dichloromethane;