20637-09-6

Basic information

• Product Name: METHYL 4-(4-AMINOPHENYL)BUTANOATE
• Synonyms: METHYL 4-(4-AMINOPHENYL)BUTANOATE;METHYL 4-(4-AMINOPHENYL)BUTYARTE;4-(4-Aminophenyl)butyricacidmethylester;4-aminophenylbutyricacidmethylester;Benzenebutanoic acid, 4-amino-, methyl ester;Butyric acid, 4-(p-aminophenyl)-, methyl ester;Methyl 4-(4-aminophenyl)butyrate;Methyl 4-aminobenzenebutanoate
• CAS NO: 20637-09-6
• Molecular Formula: C₁₁H₁₅NO₂
• Molecular Weight: 193.24
• EINECS: 243-933-0
• Mol File: 20637-09-6.mol
• Article Data: 17

Chemical Properties

• Melting Point: 42 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 323.9 °C at 760 mmHg
• Flash Point: 174.7 °C
• Appearance: /
• Density: 1.088 g/cm³
• Vapor Pressure: 0.000254mmHg at 25°C
• Refractive Index: 1.54
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 4.83±0.10(Predicted)
• CAS DataBase Reference: METHYL 4-(4-AMINOPHENYL)BUTANOATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 4-(4-AMINOPHENYL)BUTANOATE(20637-09-6)
• EPA Substance Registry System: METHYL 4-(4-AMINOPHENYL)BUTANOATE(20637-09-6)

Safety Data

• Hazardous Substances Data: 20637-09-6(Hazardous Substances Data)

Usage

Description

METHYL 4-(4-AMINOPHENYL)BUTANOATE is an organic compound that serves as an essential intermediate in the synthesis of various pharmaceuticals. It is characterized by its molecular structure, which includes a methyl group, a butanoate chain, and an aminophenyl group. This unique structure allows it to be a versatile building block in the development of new drugs and therapies.

Uses

Used in Pharmaceutical Industry:
METHYL 4-(4-AMINOPHENYL)BUTANOATE is used as a key intermediate in the synthesis of chlorambucil derivatives, which are selective anti-cancer drugs. These derivatives are particularly effective against chondrosarcoma, a type of malignant cartilaginous tissue cancer. The compound's role in the synthesis process is crucial, as it contributes to the development of drugs that can specifically target and treat this type of cancer.

InChI:InChI=1/C11H15NO2/c1-14-11(13)4-2-3-9-5-7-10(12)8-6-9/h5-8H,2-4,12H2,1H3

Upstream product

• 1520-21-4 4-vinyl benzylamine 
• 2365-48-2 Methyl thioglycolate 
• 15118-60-2 4-(4-aminophenyl)butyric Acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 67-56-1 methanol 
• 67857-97-0 4-(2-nitrophenyl)-n-butyric acid 
• 5600-62-4 4-(4-nitrophenyl)butanoic acid 
• 1821-12-1 4-Phenylbutyric acid 
• 198544-22-8 4-(4-Nitro-phenyl)-4-oxo-butyric acid methyl ester 
• 103-84-4 Acetanilid 
• 5473-15-4 4-(4-acetamidophenyl)-4-oxobutanoic acid 
• 52240-85-4 4-(4-amino-phenyl)-4-oxo-butyric acid,methyl ester 
• 198544-23-9 4,4-Difluoro-4-(4-nitro-phenyl)-butyric acid methyl ester 
• 20637-02-9 methyl 4-(4-nitrophenyl)butanoate 

Downstream Products

• 852068-07-6 5-methoxy-2-[4-(4-methoxy-4-oxobutyl)anilino]benzoic acid 
• 129948-69-2 4-[4-(phenyl-sulphonamido)phenyl]butyric acid 
• 1350618-55-1 (R)-4-(4-(3-(5-(benzyloxy)pyridin-2-yl)-2-(tert-butoxycarbonylamino)propanamido)phenyl)butanoic acid 
• 1350618-44-8 tert-butyl-1-(4-(4-(hydroxyamino)-4-oxobutyl)phenylamino)-3-(5-hydroxypyridin-2-yl)-1-oxopropan-2-ylcarbamate 
• 1350618-54-0 (R)-methyl 4-(4-(3-(5-(benzyloxy)pyridin-2-yl)-2-(tert-butoxycarbonylamino)propanamido)phenyl)butanoate 
• 1350618-43-7 R(-)-tert-butyl N-{2-[5-(benzyloxy)pyridin-2-yl]-1-({4-[3-(hydroxycarbamoyl)propyl]phenyl}carbamoyl)ethyl}carbamate 

Relevant articles and documents

Reaction of bifunctional alkylating agents with tetrahydrofolate.

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A metal-free desulfurizing radical reductive C-C coupling of thiols and alkenes

An intermolecular reductive C-C coupling of electrophilic alkyl radicals and alkenes has been developed. Thiols were used as both hydrogen-donating reagents and alkyl radical precursors in the presence of triethyl phosphite and radical initiator. A wide range of alkenes, including styrenes, and aliphatic olefins were well tolerated in this transformation. Mechanistic studies indicated that a phosphite promoted radical desulfurization of thiols to access electrophilic alkyl radicals and a radical chain propagation process may be involved in this transformation.

ANDROGEN RECEPTOR ANTAGONISTS AND USES THEREOF

Disclosed are substituted thioimidazolidinone compounds and pharmaceutical compositions comprising such compounds. The compounds and compositions can be used for treatment of androgen receptor-associated diseases or disorders, such as prostate cancer, benign prostatic hypertrophy, male hair loss and hypertrichosis.