4-chloro-1H-indole-5-carboxylic acid ((S)-1-cyclohexyl-2-hydroxyethyl)amide

Base Information

Chemical Name:4-chloro-1H-indole-5-carboxylic acid ((S)-1-cyclohexyl-2-hydroxyethyl)amide
CAS No.:1616256-00-8
Molecular Formula:C₁₇H₂₁ClN₂O₂
Molecular Weight:320.819
Hs Code.:

Synonyms:4-chloro-1H-indole-5-carboxylic acid ((S)-1-cyclohexyl-2-hydroxyethyl)amide

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Chemical Property of 4-chloro-1H-indole-5-carboxylic acid ((S)-1-cyclohexyl-2-hydroxyethyl)amide

Chemical Property:

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Technology Process of 4-chloro-1H-indole-5-carboxylic acid ((S)-1-cyclohexyl-2-hydroxyethyl)amide

There total 6 articles about 4-chloro-1H-indole-5-carboxylic acid ((S)-1-cyclohexyl-2-hydroxyethyl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 251107-41-2
4-chloro-indole-5-carboxylic acid

: 845714-30-9
(S)-2-amino-2-cyclohexylethan -1-ol

: 1616256-00-8
4-chloro-1H-indole-5-carboxylic acid ((S)-1-cyclohexyl-2-hydroxyethyl)amide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 1613730-03-2
methyl 4-amino-2-chloro-3-ethynylbenzoate

: 1616256-00-8
4-chloro-1H-indole-5-carboxylic acid ((S)-1-cyclohexyl-2-hydroxyethyl)amide

Guidance literature:: Multi-step reaction with 3 steps

1: P(p-C₆H₄F)3; chloro(1,5-cyclooctadiene)rhodium(I) dimer / N,N-dimethyl-formamide / 0.83 h / 85 °C / Inert atmosphere

2: lithium hydroxide / methanol; water / 45 - 65 °C

3: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide; dichloromethane / 20 °C

With chloro(1,5-cyclooctadiene)rhodium(I) dimer; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; P(p-C₆H₄F)3; In methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 2457-76-3
4-amino-2-chlorobenzoic acid

: 1616256-00-8
4-chloro-1H-indole-5-carboxylic acid ((S)-1-cyclohexyl-2-hydroxyethyl)amide

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetyl chloride / 5 h / Reflux

2.1: iodine; silver sulfate / ethanol / 0.25 h / Inert atmosphere

2.2: 1.5 h / 60 - 70 °C / Inert atmosphere

3.1: potassium carbonate / methanol / 0.25 h

4.1: P(p-C₆H₄F)3; chloro(1,5-cyclooctadiene)rhodium(I) dimer / N,N-dimethyl-formamide / 0.83 h / 85 °C / Inert atmosphere

5.1: lithium hydroxide / methanol; water / 45 - 65 °C

6.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide; dichloromethane / 20 °C

With chloro(1,5-cyclooctadiene)rhodium(I) dimer; iodine; potassium carbonate; benzotriazol-1-ol; silver sulfate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; acetyl chloride; lithium hydroxide; P(p-C₆H₄F)3; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;