tert-butyl 7-[(S)-2-phenyl-1-(2,2,2-trichloroethoxycarbonyl)-ethyl]-6,8,10-trioxo-1,7,9-triaza-spiro[4.5]decane-1-carboxylate

Base Information

• Chemical Name: tert-butyl 7-[(S)-2-phenyl-1-(2,2,2-trichloroethoxycarbonyl)-ethyl]-6,8,10-trioxo-1,7,9-triaza-spiro[4.5]decane-1-carboxylate
• CAS No.: 1020666-29-8
• Molecular Formula: C₂₃H₂₆Cl₃N₃O₇
• Molecular Weight: 562.834

Synonyms:tert-butyl 7-[(S)-2-phenyl-1-(2,2,2-trichloroethoxycarbonyl)-ethyl]-6,8,10-trioxo-1,7,9-triaza-spiro[4.5]decane-1-carboxylate

Chemical Property of tert-butyl 7-[(S)-2-phenyl-1-(2,2,2-trichloroethoxycarbonyl)-ethyl]-6,8,10-trioxo-1,7,9-triaza-spiro[4.5]decane-1-carboxylate

Chemical Property:

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Technology Process of tert-butyl 7-[(S)-2-phenyl-1-(2,2,2-trichloroethoxycarbonyl)-ethyl]-6,8,10-trioxo-1,7,9-triaza-spiro[4.5]decane-1-carboxylate

There total 1 articles about tert-butyl 7-[(S)-2-phenyl-1-(2,2,2-trichloroethoxycarbonyl)-ethyl]-6,8,10-trioxo-1,7,9-triaza-spiro[4.5]decane-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

tert-butyl 7-((S)-1-carboxy-2-phenylethyl)-6,8,10-trioxo-1,7,9-triaza-spiro[4.5]decane-1-carboxylate (1020666-19-6) + 1,1,1-trichloroethanol (115-20-8) → tert-butyl 7-[(S)-2-phenyl-1-(2,2,2-trichloroethoxycarbonyl)-ethyl]-6,8,10-trioxo-1,7,9-triaza-spiro[4.5]decane-1-carboxylate (1020666-29-8)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 18h;

DOI:10.1021/jo702573z

Reference yield: 85.0%

2-(4-bromomethylphenoxymethyl)-1,3-dichlorobenzene (263356-20-3) + tert-butyl 7-[(S)-2-phenyl-1-(2,2,2-trichloroethoxycarbonyl)-ethyl]-6,8,10-trioxo-1,7,9-triaza-spiro[4.5]decane-1-carboxylate (1020666-29-8) → tert-butyl 9-[4-(2,6-dichlorobenzyloxy)benzyl]-7-[(S)-2-phenyl-1-(2,2,2-trichloroethoxycarbonyl)-ethyl]-6,8,10-trioxo-1,7,9-triaza-spiro[4.5]decane-1-carboxylate (1020666-34-5)

Guidance literature:

With sodium hydride; In hexane; N,N-dimethyl-formamide; at 20 ℃; for 16h;

DOI:10.1021/jo702573z

Reference yield: 85.0%

tert-butyl 7-[(S)-2-phenyl-1-(2,2,2-trichloroethoxycarbonyl)-ethyl]-6,8,10-trioxo-1,7,9-triaza-spiro[4.5]decane-1-carboxylate (1020666-29-8) + methyl iodide (74-88-4) → tert-butyl 9-methyl-7-[(S)-2-phenyl-1-(2,2,2-trichloroethoxycarbonyl)-ethyl]-6,8,10-trioxo-1,7,9-triaza-spiro[4.5]decane-1-carboxylate (1020666-33-4)

Guidance literature:

With sodium hydride; In hexane; N,N-dimethyl-formamide; at 20 ℃; for 16h;

DOI:10.1021/jo702573z

upstream raw materials:

tert-butyl 7-((S)-1-carboxy-2-phenylethyl)-6,8,10-trioxo-1,7,9-triaza-spiro[4.5]decane-1-carboxylate

1,1,1-trichloroethanol

Downstream raw materials:

tert-butyl 9-[4-(2,6-dichlorobenzyloxy)benzyl]-7-[(S)-2-phenyl-1-(2,2,2-trichloroethoxycarbonyl)-ethyl]-6,8,10-trioxo-1,7,9-triaza-spiro[4.5]decane-1-carboxylate

tert-butyl 9-methyl-7-[(S)-2-phenyl-1-(2,2,2-trichloroethoxycarbonyl)-ethyl]-6,8,10-trioxo-1,7,9-triaza-spiro[4.5]decane-1-carboxylate

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