2-(4-(8-bromo-1H-imidazo[4,5-c]cinnolin-1-yl)phenyl)-2-methylpropanenitrile

Base Information

Chemical Name:2-(4-(8-bromo-1H-imidazo[4,5-c]cinnolin-1-yl)phenyl)-2-methylpropanenitrile
CAS No.:1366050-71-6
Molecular Formula:C₁₉H₁₄BrN₅
Molecular Weight:392.258
Hs Code.:

Synonyms:2-(4-(8-bromo-1H-imidazo[4,5-c]cinnolin-1-yl)phenyl)-2-methylpropanenitrile

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Chemical Property of 2-(4-(8-bromo-1H-imidazo[4,5-c]cinnolin-1-yl)phenyl)-2-methylpropanenitrile

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Technology Process of 2-(4-(8-bromo-1H-imidazo[4,5-c]cinnolin-1-yl)phenyl)-2-methylpropanenitrile

There total 8 articles about 2-(4-(8-bromo-1H-imidazo[4,5-c]cinnolin-1-yl)phenyl)-2-methylpropanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 64-18-6
formic acid

: 1366050-70-5
2-(4-(3-amino-6-bromocinnolin-4-ylamino)phenyl)-2-methylpropanenitrile

: 1366050-71-6
2-(4-(8-bromo-1H-imidazo[4,5-c]cinnolin-1-yl)phenyl)-2-methylpropanenitrile

Guidance literature:: for 4h; Inert atmosphere; Reflux;

Reference yield:

: 29124-64-9
N-(2-acetyl-4-bromophenyl)acetamide

: 1366050-71-6
2-(4-(8-bromo-1H-imidazo[4,5-c]cinnolin-1-yl)phenyl)-2-methylpropanenitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride / tetrahydrofuran / 1 h / Inert atmosphere; Reflux

1.2: 15 h / 0 - 20 °C

2.1: sulfuric acid; nitric acid / 3 h / 0 - 60 °C

3.1: trichlorophosphate / N,N-dimethyl-formamide / 5 h / 0 - 20 °C

4.1: potassium carbonate / acetonitrile / 0.08 h / Reflux

5.1: tin(II) chloride hydrate / ethyl acetate / 3 h / 45 °C

6.1: 4 h / Reflux

With hydrogenchloride; tin(II) chloride hydrate; sulfuric acid; nitric acid; potassium carbonate; trichlorophosphate; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 876-88-0
6-bromocinnolin-4-ol

: 1366050-71-6
2-(4-(8-bromo-1H-imidazo[4,5-c]cinnolin-1-yl)phenyl)-2-methylpropanenitrile

Guidance literature:: Multi-step reaction with 5 steps

1: sulfuric acid; nitric acid / 3 h / 0 - 60 °C

2: trichlorophosphate / N,N-dimethyl-formamide / 5 h / 0 - 20 °C

3: potassium carbonate / acetonitrile / 0.08 h / Reflux

4: tin(II) chloride hydrate / ethyl acetate / 3 h / 45 °C

5: 4 h / Reflux

With tin(II) chloride hydrate; sulfuric acid; nitric acid; potassium carbonate; trichlorophosphate; In ethyl acetate; N,N-dimethyl-formamide; acetonitrile;