29124-64-9

Usage

Uses

Used in Pharmaceutical Research:
N-(2-acetyl-4-bromophenyl)acetamide is utilized as a pharmaceutical intermediate for the development of various drugs. Its anti-inflammatory and analgesic properties make it a promising candidate for the treatment of pain and inflammation.
Used in Organic Synthesis:
In the field of organic synthesis, N-(2-acetyl-4-bromophenyl)acetamide serves as a key intermediate. Its unique structure allows for the creation of a variety of organic compounds, contributing to the advancement of chemical research and the production of novel materials.
Used in Drug Development:
N-(2-acetyl-4-bromophenyl)acetamide's chemical properties make it a valuable resource in the development of new drugs. Its potential applications in medicine are being explored, with a focus on leveraging its anti-inflammatory and analgesic effects for therapeutic purposes.
Used in Chemical Compound Production:
N-(2-acetyl-4-bromophenyl)acetamide is also employed in the production of other chemical compounds, where its specific structural features are beneficial for achieving desired chemical reactions and outcomes.

Upstream product

• 4583-55-5 5-bromo-2,3-dimethyl-1H-indole 
• 29124-56-9 1-(2-amino-5-bromophenyl)ethanone 
• 108-24-7 acetic anhydride 
• 551-93-9 2-aminoacetophenone 
• 5234-26-4 N-(2-acetylphenyl)acetamide 

Downstream Products

• 1225273-58-4 N-[2-acetyl-4-(4-methylpiperazin-1-yl)phenyl]acetamide 
• 2316-33-8 N-Acetyl-2-amino-5-brom-acetophenonoxim 
• 68211-13-2 4,6-dichlorocinnoline 
• 1366050-71-6 2-(4-(8-bromo-1H-imidazo[4,5-c]cinnolin-1-yl)phenyl)-2-methylpropanenitrile 
• 1366050-29-4 2-(4-(8-(6-amino-5-(trifluoromethyl)pyridin-3-yl)-1H-imidazo[4,5-c]cinnolin-1-yl)phenyl)-2-methylpropanenitrile 
• 1366050-70-5 2-(4-(3-amino-6-bromocinnolin-4-ylamino)phenyl)-2-methylpropanenitrile 
• 1366050-69-2 2-(4-(6-bromo-3-nitrocinnolin-4-ylamino)phenyl)-2-methylpropanenitrile 
• 876-88-0 6-bromocinnolin-4-ol 
• 876-88-0 6-bromo-1H-cinnolin-4-one 
• 63362-11-8 1-(2-amino-5-bromo-phenyl)-ethanone; hydrochloride 
• 68211-15-4 6-bromo-4-chlorocinnoline 
• 318276-72-1 6-bromocinnoline 
• 29124-56-9 1-(2-amino-5-bromophenyl)ethanone 
• 65340-70-7 6-bromo-4-chloroquinoline 

Relevant academic research and scientific papers

Auto-tandem PET and EnT photocatalysis by crude chlorophyll under visible light towards the oxidative functionalization of indoles

Chlorophyll is the most abundant photocatalytic pigment that enables plants to absorb solar energy and convert it to energy storage molecules. Herein, we report a tandem photocatalytic approach utilizing the natural pigment chlorophyll in crude form to achieve photoinduced electron transfer (PET) and energy transfer (EnT) towards the oxidative functionalization of indoles. Redox potentials, ESR, fluorescence quenching and UV experiments have evidenced the dual catalytic activity of chlorophyll. The highlight of the study is the auto-tandem photocatalytic role of chlorophyll to enable the green oxidation of indoles using molecular oxygen as the oxidant, water as the reaction medium, and photochemical energy from the visible region of the spectrum.

Discovery of Pyridopyrimidinones as Potent and Orally Active Dual Inhibitors of PI3K/mTOR

The identification and lead optimization of a series of pyridopyrimidinone derivatives are described as a novel class of efficacious dual PI3K/mTOR inhibitors, resulting in the discovery of 31. Compound 31 exhibited high enzyme activity against PI3K and mTOR, potent suppression of Akt and p70s6k phosphorylation in cell assays, and good pharmacokinetic profile. Furthermore, compound 31 demonstrated in vivo efficacy in a PC-3M tumor xenograft model.

Thiazolidine derivatives or salts thereof as an active ingredient an inhibitor Pim

PROBLEM TO BE SOLVED: To provide compounds which have excellent Pim inhibitory action and are useful as pharmaceuticals.SOLUTION: A compound is a thiazolidine derivative represented by the general formula (1) in the figure, or a salt thereof. (In the formula, X represents O or S; Rrepresents a hydrogen atom or a Calkyl group; Z, Z, Z, Z, Zand Zeach independently represent CH or N; Y represents an optionally substituted, divalent Caromatic hydrocarbon group or the like; Am represents a disubstituted amino group, or an optionally substituted, nitrogen-containing saturated heterocyclic group; and Rand Reach independently represent a hydrogen atom, a halogen atom, an alkyl group or the like.)

Intermolecular Aryl C?H Amination through Sequential Iron and Copper Catalysis

A mild, efficient and regioselective method for para-amination of activated arenes has been developed through a combination of iron and copper catalysis. A diverse range of products were obtained from an operationally simple one-pot, two-step procedure involving bromination of the aryl substrate with the powerful Lewis acid iron(III) triflimide, followed by a copper(I)-catalysed N-arylation reaction. This two-step dehydrogenative process for the regioselective coupling of aromatic C?H bonds with non-activated amines was applicable to anisole-, phenol-, aniline- and acetanilide-type aryl compounds. Importantly, the arene substrates were used as the limiting reagent and required no protecting-group manipulations during the transformation.

Discovery of a novel series of thienopyrimidine as highly potent and selective PI3K inhibitors

Inhibition of the phosphoinositide 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway provides a promising new approach for cancer therapy. Through a rational design, a novel series of thienopyrimidine was discovered as highly pote

FUSED HETEROARYLS AND THEIR USES

Provided are certain fused heteroaryls, compositions thereof and methods of use therefor.

FUSED HETEROARYLS AND THEIR USES

Provided are certain fused heteroaryls, compositions thereof and methods of use therefor.

Identification of 4,5-dihydro-1 H -pyrazolo[4,3- h ]quinazoline Derivatives as a new class of orally and selective polo-like kinase 1 inhibitors

Polo-like kinase 1 (Plk1) is a fundamental regulator of mitotic progression whose overexpression is often associated with oncogenesis and therefore is recognized as an attractive therapeutic target in the treatment of proliferative diseases. Here we discuss the Structure-activity relationship of the 4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline class of compounds that emerged from a high throughput screening (HTS) campaign as potent inhibitors of Plk1 kinase. Furthermore, we describe the discovery of 49, 8-{[2-methoxy-5-(4- methylpiperazin-1-yl)phenyl]amino}-1-methyl-4,5-dihydro-1H-pyrazolo[4,3-h] quinazoline-3-carboxamide, as a highly potent and specific ATP mimetic inhibitor of Plk1 (IC50 = 0.007 μM) as well as its crystal structure in complex with the methylated Plk136-345 construct. Compound 49 was active in cell proliferation against different tumor cell lines with IC 50 values in the submicromolar range and active in vivo in the HCT116 xenograft model where it showed 82% tumor growth inhibition after repeated oral administration.

SUBSTITUTED PYRAZOLO-QUINAZOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS

Pyrazolo-quinazoline derivatives of formula (I) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may

Oxidative cleavage reaction of substituted indoles catalyzed by plant cell cultures

We have developed a novel method for the oxidative cleavage of indole carbon double bonds in the presence of H2O2 using plant cell cultures as peroxidase. The oxidative method has some advantage, as features such as mild reactions, good yields, easy work-up and safety.